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| Short-term Clinical Efficacy of Laparoscopic and Open D2 Radical Operations for Carcinoma of Stomach and the Influence on Serum Inflammatory Factor Levels |
| ZHANG Qi, HE Changlin |
| The People's Hospital of Dujiangyan, Sichuan Dujiangyan 611830, China |
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Abstract Objective: To compare the short-term clinical efficacy between laparoscopic and open D2 radical operations for carcinoma of stomach and the changes in serum inflammatory factor levels. Methods: Totally 60 eligible patients were collected and divided into laparoscopic group (32 patients) and open group (28 patients) based on the wills of the patients and the families. The surgical resection conditions, postoperative recovery conditions, and serum levels of C reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) before the surgeries and at 3d after the surgeries in the patients of the two groups were recorded. Results: The patients of the two groups had insignificantly different total numbers of cleared lymph nodes, distances between the distal resection ends and the tumors, and distances between the proximal resection ends and the tumors (P>0.05). The laparoscopic group had significantly better intraoperative blood loss, postoperative times to passage of gas by anus, to out-of-bed activity, and to eating liquid diet, and postoperative length of stay than those in the open group (all P<0.05). Before the surgeries, the patients of the two groups had insignificantly different serum levels of CRP, IL-6 and TNF-α (P>0.05); 3 days after the surgeries, the laparoscopic group had significantly lower serum levels of CRP, IL-6 and TNF-α than those in the open group (P<0.05). The laparoscopic group had significantly lower complication incidence than the open group (6.25% vs. 32.14%, P<0.05). Conclusion: Laparoscopic D2 radical operation for carcinoma of stomach causes small wound, clears lymph nodes thoroughly, has mild postoperative inflammatory reactions and good short-term clinical efficacy, and is beneficial to the rehabilitation.
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2016, Vol. 22 
