丁苯酞序贯联合静脉溶栓对急性脑梗死患者sdLDL-C Annexin A2 Hcy及预后的影响

doi:10.3969/j.issn.1006-6233.2022.06.031

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Abstract Objective: To analyze the effect of sequential butylphthalide combined with intravenous thrombolysis on small dense low density lipoprotein cholesterol (sdLDL-C), annexin A2, homocysteine (Hcy) and prognosis in patients with acute cerebral infarction. Methods: Totally 148 patients with acute cerebral infarction admitted to our hospital from June 2016 to June 2021 were randomly divided into butylphthalide group and control group, 74 cases in each group, all of which were treated with conventional comprehensive treatment and intravenous thrombolysis, while butylphthalide group was treated with butylphthalide sequentially. The levels of serum sdLDL-C, Annexin A2 and Hcy in the two groups were detected before and 4 weeks after treatment, and the prognosis was evaluated according to the changes of NIHSS neurological deficit score and Barthel index (BI) before and after treatment. Results: 4 weeks after treatment, serum sdLDL-C and Hcy in both groups were lower than before treatment, and Annexin A2 was higher than before treatment; the changes of serum sdLDL-C, Hcy and Annexin A2 in phthalide group were larger than those in control group (P<0.05). 12 weeks after treatment, the NIHSS score of both groups decreased and BI index increased; NIHSS score and BI index in phthalide group changed more than those in control group (P<0.05). The incidence of adverse reactions in butylphthalide group and control group during treatment was 9.46% and 10.81% respectively, and there was no statistical difference between the two groups (P>0.05). Conclusion: Sequential treatment with butylphthalide on the basis of intravenous thrombolysis can not only regulate the levels of sdLDL-C, Annexin A2 and Hcy in patients with acute cerebral infarction, but also improve the prognosis quality of patients by promoting the recovery of neurological function and living ability, with good safety.

Key words： Acute cerebral infarction Butylphthalide Sequential treatment Intravenous thrombolysis Annexin A2

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	WU Yunhong
	ZHOU Hui
	CHEN Wei
	et al

Cite this article:

WU Yunhong,ZHOU Hui,CHEN Wei, et al. Effects of Sequential Butylphthalide Combined with Intravenous Thrombolysis on sdLDL-C Annexin A2, Hcy and Prognosis in Patients with Acute Cerebral Infarction[J]. HeBei Med, 2022, 28(6): 1020-1023.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.06.031 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I6/1020

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