地西泮对高热惊厥复发患儿热退发热和惊厥复发免疫球蛋白水平和血清NSE水平的影响

doi:10.3969/j.issn.1006-6233.2022.06.028

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Abstract Objective: To analyze the effects of diazepam on fever regression, fever and convulsion recurrence, immunoglobulin level and serum NSE level in children with recurrent febrile convulsion. Methods: A total of 200 children with convulsion admitted to our hospital from January 2019 to January 2021 were randomly divided into control group (given general treatment) and experimental group (given diazepam + general treatment), with 100 cases in each group. The fever regression, fever and convulsion recurrence, immunoglobulin level and serum NSE level of children with recurrent febrile convulsion in the two groups were recorded. Results: Analysis of variance (ANOVA) on repeated measurements showed statistically significant differences in body temperature between the 2 groups, in time and in the interaction between groups and time (P<0.05). There was no significant difference in IgG levels and IgA levels between the 2 groups 1 d before and 3 weeks after treatment compared to the control group (P>0.05).There was no significant difference in IgG levels and IgA levels between the 2 groups 1 d before and 3 weeks after treatment (P>0.05).There was no significant difference in serum NSE levels between the 2 groups before treatment (P>0.05). The serum NSE level was lower in both groups 3 weeks after treatment than before treatment, and the serum NSE level was lower in the test group than in the control group after treatment (P<0.05). In the control group, there were 10 cases of fever recurrence and 7 cases of convulsion recurrence; in the test group, there were 2 cases of fever recurrence and 0 cases of convulsion recurrence. The difference in the incidence of fever recurrence and convulsion recurrence between the 2 groups was statistically significant (χ²=5.674, 7.254; P<0.05). Conclusion: Diazepam improves clinical outcomes and reduces clinical symptoms in children with recurrent febrile convulsions, and the therapy has a high degree of efficacy and safety, with no significant improvement in immune function.

Key words： High fever Convulsions Diazepam Serum NSE Immunoglobulin level

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	ZHANG Jing
	WANG Fengjuan
	SUN Yanyan

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ZHANG Jing,WANG Fengjuan,SUN Yanyan. Effects of Diazepam on Fever Regression Rever and Convulsion Recurrence Immunoglobulin Level and Serum NSE Level in Children with Recurrent Febrile Convulsion[J]. HeBei Med, 2022, 28(6): 1007-1010.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.06.028 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I6/1007

[1] Hashimoto R,Suto M,Tsuji M,et al.Use of antipyretics for preventing febrile seizure recurrence in children:a systematic review and meta-analysis[J].Eur Pediatr,2021,180(4):987-997.
[2] 郝改领,徐丽娟,常海霞,等.NSE、GFAP、ADM在热性惊厥患儿血清中变化与神经功能损伤的关系[J].现代医学,2020,48(4):452-455.
[3] Jain S,Santhosh A.Febrile seizures:Evidence for evolution of an operational strategy from an armed frces referral hospital[J].Pediatric Health Med Ther,2021,12(1):151-159.
[4] Sugitate R,Okubo Y,Nariai H,et al.The effects of antihistamine on the duration of the febrile seizure:a single center study with a systematic review and meta-analysis[J].Brain Dev,2020,42(2):103-112.
[5] 中华医学会儿科学分会神经学组.热性惊厥诊断治疗与管理专家共识(2017实用版)[J].中华实用儿科临床杂志,2017,32(18):1379-1382.
[6] Renda R,Yüksel D,Gürer Y K Y.Evaluation of patients with febrile seizure:risk factors,reccurence,treatment and prognosis[J].Pediatr Emerg Care,2020,36(4):173-177.
[7] Rakgantsho C,Mabandla M V.Acetylcholine receptor agonist effect on seizure activity and GABAergic mechanisms involved in prolonged febrile seizure development in an animal model[J].Brain Res Bull,2019,149(1):203-207.
[8] 邓琴芹,廖超平,黄春菊,等.热性惊厥患儿血清hs-CRP、H-FABP与心肌损伤的关系[J].中国妇幼健康研究,2020,31(7):942-946.
[9] Pollock L A,Newton E J,Koen E L.Predicting high-risk areas for African swine fever spread at the wild-domestic pig interface in Ontario[J].Preventive Veterinary Medicine,2021,191(1):105341.
[10] Arul J,Kommu P P K,Kasinathan A,et al.Zinc status and febrile seizures:Results from a cross-sectional study[J].Neurosci Rural Pract,2020,11(4):597-600.
[11] Freedman D A,Vidaurre J.Long-term risks of recurrent febrile seizures[J].Pediatr Neurol Briefs,2020,34(1):22.
[12] Mewasingh L D,Chin R F M,Scott R C.Current understanding of febrile seizures and their long-term outcomes[J].Dev Med Child Neurol,2020,62(11):1245-1249.
[13] 丁鸿飞,朱香兰,章笑安,等.左乙拉西坦治疗小儿热性惊厥的效果及对血清神经元特异性烯醇化酶,S-100β蛋白表达的影响[J].中国医药导报,2019,16(36):119-122.