难治性部分性癫痫应用加巴喷丁添加治疗的疗效及安全性分析

doi:10.3969/j.issn.1006-6233.2017.06.013

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Abstract Objective: To investigate the efficacy and safety analysis of Gaba Martin Add treatment in the treatment of Refractory partial epilepsy patients. Method: 70 Refractory partial epilepsy patients admitted to neurology department of our hospital were selected and randomly divided into the control group and the experiment group with 35 cases in each group. The control group was given a Carbamazepine Tablets starting dose of 5mg/kg daily, gradually increased to 20 mg/kg. Topiramate Tablets starting dose of 0.8mg/kg per day could be gradually increased to 7mg/kg. The patients in the experimental group were added gabapentin Capsule on the basis of the control group. First gabapentin capsules 300mg orally every time, 1 times a day, second doses of gabapentin capsules 300mg orally every day, 2 times a day, third days until the end of treatment for gabapentin capsules 300mg oral every time, 3 times a day. Two groups of patients were treated for a period of 6 months. After treatment, the clinical efficacy, memory function, the degree of neurological deficit, T lymphocyte group, serum immunoglobulin and adverse reactions were compared between the two groups. Results: After treatment, 2 weeks after the onset of the attack frequency and the frequency of attack after 12 weeks was lower than the baseline frequency. Compared with before treatment, after treatment, the 2 groups of CMS score increased, NFDS score decreased, IgA, IgG and IgM levels decreased, serum CD³⁺, CD⁴⁺, CD⁴⁺/ CD⁸⁺ increased(P＜0.05). Compared with the control group, the total effective rate of treatment group was higher after 4 weeks, 12 weeks after the onset of lower frequency, higher CMS scores, lower NFDS score, IgA, IgG and IgM low level of serum CD³⁺, CD⁴⁺, CD⁴⁺/, CD⁸⁺ high and low incidence rate of adverse reaction, the difference has statistical significance(P＜0.05). There was no significant difference between the 2 groups before and after treatment with CD⁸⁺(P＞0.05). Conclusion: The clinical efficacy of gabapentin in the treatment of refractory partial epilepsy is significant. It can improve the memory function, nerve function and immune function of patients.

Key words： Refractory partial epilepsy Gaba martin Clinical efficacy Safety

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.06.013 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I6/923

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