骨保护素及骨硬化蛋白水平与维持透析患者冠状动脉钙化程度的关系

doi:10.3969/j.issn.1006-6233.2022.05.028

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Abstract Objective: To explore the correlation between serum osteoprotegerin(OPG)or sclerostin(SO)level and coronary artery calcification(CAC)occurrence as well as related score(CAC score,CACS)in maintenance dialysis patients. Methods: 183 patients who received maintenance dialysis treatment in our department from November 2018 to November 2020 were selected as the research objects. Those with CACS ≤ 100 were included in the low group (80 cases) and those with CACS > 100 were included in the high group (103 cases). The clinical data of patients were collected and the levels of serum OPG and so were detected. Univariate analysis and multiple linear regression were used to analyze the independent risk factors of CAC in maintenance dialysis patients, and the correlation between OPG and so levels and CACS score was analyzed. Results: The age of dialysis and the number of diabetes in high group were higher than those in low group (P<0.05). The levels of serum CRP, OPG and so in high group were higher than those in low group (P<0.05); OPG level (r = 0.871, P = 0.000) and so level (r = 0.772, P = 0.000) were positively correlated with CACS score; Dialysis age, OPG, so and CRP levels were independent risk factors for coronary artery calcification in maintenance dialysis patients (P<0.05). Conclusion: The levels of serum OPG and so in maintenance dialysis patients are related to the occurrence of CAC. They may become a reliable means to predict CAC in the future.

Key words： Dialysis OPG SO CAC

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	DENG Zhenzhen
	CHEN Cheng
	XIONG Shuzhen
	et al

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DENG Zhenzhen,CHEN Cheng,XIONG Shuzhen, et al. Relationship between the Levels of Osteoprotegerin and Osteosclerosis Protein and the Degree of Coronary Artery Calcification in Maintenance Dialysis Patients[J]. HeBei Med, 2022, 28(5): 834-838.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.05.028 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I5/834

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