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| Expression Levels of X-Chromosome-Linked Zinc Finger Protein and Axin in Gastric Cancer Tissues and Correlation with Clinicopathological Factors |
| ZHENG Wei, et al |
| The First Affiliated Hospital of Fujian Medical University,Fujian Fuzhou 350005, China |
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Abstract Objective: To analyze the expression levels of X-chromosome-linked zinc finger protein and axin expression levels in gastric cancer tissues and their correlation with clinicopathological factors. Methods: From Feb. 2018 to Feb. 2021, 300 patients with gastric cancer in our hospital were retrospectively selected, and 300 cases of their gastric cancer tissues and 140 cases of their paracancerous tissues (more than 5.0 cm away from the gastric cancer tissues) were surgically excised down, and the expression of ZFX and Axin in gastric cancer tissues and paracancerous tissues were statistically analyzed, and the correlation between the expression of ZFX and Axin in gastric cancer tissues and clinicopathological factors was analyzed. Results: The positive rate of ZFX expression in gastric cancer tissues was 84.33% (253/300) higher than that in paraneoplastic tissues 17.14% (24/140), and the negative rate was 15.67% (47/300) lower than that in paraneoplastic tissues 82.86% (116/140) (P<0.05); the positive rate of Axin expression was 34.00% (102/300) lower than that in paraneoplastic tissues 84.29% (118/140) and the negative rate was 66.00% (198/300) higher than that of 15.71% (22/140) in paraneoplastic tissues (P<0.05). The positive rate of ZFX expression in gastric cancer tissues of patients with Duke stage I-II was lower than that of patients with stage III-IV (P<0.05), the positive rate of ZFX expression in gastric cancer tissues of patients with low, medium and high differentiation gradually decreased (P<0.05), the positive rate of ZFX expression in gastric cancer tissues of patients with infiltration depth of outer mucosal layer, mucosal layer, mucosa and submucosa gradually decreased (P<0.05). The positive rate of ZFX expression in gastric cancer tissues of patients with lymph node metastasis was higher than that of patients without lymph node metastasis (P<0.05). The positive rate of Axin expression in gastric cancer tissues of patients with Duke stage I-II was higher than that of patients with stage III-IV (P<0.05). The positive rate of Axin expression in gastric cancer tissues of patients with low, medium and high differentiation gradually increased (P<0.05). The positive rate of Axin expression in gastric cancer tissues of patients with lymph node metastasis was lower than that of patients without lymph node metastasis (P<0.05). Conclusion: The positive expression rate of X-linked zinc finger protein and axin in gastric cancer tissues is increased and decreased, which are related to Duke stage, degree of differentiation, depth of invasion and lymph node metastasis in clinicopathological factors.
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2022, Vol. 28 
