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| Clinical Study on Acupuncture and Moxibustion Combined with Huanglian Wendan Decoction in the Treatment of Stroke Sleep Disorder with Phlegm Heat Disturbing Heart Syndrome |
| SU Guochun, ZHONG Haiyan, WEI Yin, et al |
| Qinzhou First People's Hospital,Guangxi Qinzhou 535000, China |
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Abstract Objective: To study the clinical efficacy of acupuncture and moxibustion combined with Huanglian Wendan Decoction in the treatment of stroke sleep disorder with phlegm heat disturbing heart syndrome. Methods: Totally 100 stroke patients admitted to the First People's Hospital of Qinzhou City from July 2019 to June 2020 were collected and divided into a study group and a control group, 50 cases each. Control group was treated with Huanglian Wendan Decoction, and the study group was treated with acupuncture and moxibustion combined with Huanglian Wendan Decoction, with 4 weeks as 1 course of treatment for 3 courses. The clinical efficacy of the two groups were compared, the score of TCM symptoms was evaluated, and the TCM symptom score, sleep quality by polysomnography, and neurotrophic factor levels by enzyme immunoassay were assessed before and after treatment to observe the occurrence of adverse effects.Results: The total effective rate was 94.00% in the study group, higher than that of the control group at 76.00% (P<0.05). After treatment, the TCM symptom scores (sleep disturbance, distraction and chagrin, dizziness and chest tightness, red tongue with yellow coating), as well as sleep latency, rapid eye movement sleep time, wakefulness time and Pittsburgh Sleep Quality Index score (PSQI) were lower in both groups than before treatment, and the above indicators were lower in the study group than in the control group, and the difference was statistically significant (P<0.05). After treatment, the total sleep time and serum levels of brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) in both groups were higher than those before treatment, and all these indexes in the study group were higher than those in the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions during the treatment period was 14.00% and 10.00% in the study group and the control group respectively, with no difference between the groups (P>0.05). Conclusion: The combination of acupuncture and moxibustion with Huang Lian Wen Bile Tang was effective in treating patients with sleep disorders in stroke with phlegm-heat disturbing the heart, improving the patients' TCM symptoms and sleep quality, and increasing the level of neurotrophic factors in stroke patients with better treatment safety.
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2022, Vol. 28 
