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| Clinical Study of Solitaire Stent Semi-Release Protection Technique Combined with Local Thrombolysis in the Treatment of Severe Intracranial Venous Sinus Thrombosis |
| TANG Chao, SHEN Junhui, GAO Wei, et al |
| Hunan Brain Hospital / Hunan Second People's Hospital, Hunan Changsha 410006, China |
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Abstract Objective: To explore the clinical value of Solitaire stent-retriever half-release protection (SHARP) combined with local thrombelysis in the treatment of severe intracranial sinus thrombosis (CVST). Methods: The clinical data of 143 patients with severe CVST admitted to our hospital from April 2016 to April 2020 were collected. According to the treatment protocols, 74 patients who received anticoagulation + local thrombolysis were included in the control group, and 69 patients who received anticoagulation + local thrombolysis + SHARP technique for thrombolysis were included in the study group. The duration of thrombolytic therapy, length of hospital stay, recanalization, occurrence of complications, Glasgow Coma Scale (GCS), Glasgow Outcome Scale (Glasgow Outcome Scale) and Coagulation and fibrinolysis function before and after treatment were compared between the two groups. GOS (GOS), Modified Rankin Scale (mRS) scores before and after treatment were compared between the two groups. And the prognosis of patients was evaluated according to mRS score at 6 months after treatment.Results: The duration of thrombolytic therapy in the study group was lower than that in the control group, the difference was statistically significant (P<0.05). The revascularization rate of the study group was 95.65%, higher than the control group at 77.03%, the difference was statistically significant (P<0.05). The complication rate in the study group was 4.35%, and 18.92% in the control group. The complication rate in the study group was lower than that in the control group, and the difference was statistically significant (P=0.007). The GCS score and GOS score 1 d before discharge in both groups increased and the mRS score decreased compared with those before treatment. The increase of GCS score and GOS score in the study group 1 day before discharge was higher than that in the control group, and the decrease of mRS score was higher than that in the control group, and the difference was statistically significant (P<0.05). In both groups, APTT, PT and TT were all higher and FIB and D-D were lower 1 d before discharge than before treatment; in the study group, APTT, PT and TT were all higher and FIB and D-D were all lower 1 d before discharge than in the control group. Patients in both groups were effectively followed up. At 6 months postoperatively, the good prognosis rate was 65.22% in the study group, higher than that of 32.43% in the control group, with a statistically significant difference (P=0.001).Conclusion: On the basis of anticoagulation and local thrombolysis, SHARP technique can shorten the thrombolysis time, improve the revascularization rate, reduce the incidence of complications and improve the prognosis of patients with severe CVST.
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2022, Vol. 28 
