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| Association of Serum miR-647 PTEN and In-Stent Restenosis After PCI in Patients with ACS |
| XU Jing, BAI Jing, CUI Qianwei, et al |
| Shaanxi People's Hospital, Shaanxi Xi'an 710068, China |
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Abstract Objective: To investigate the association of serum microRNA (miRNA)-647, phosphatase and tensin homolog deleted on chromosome ten (PTEN) with in-stent restenosis after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). Methods: A total of 209 patients with ACS were divided into restenosis group (n=45) and non-restenosis group (n=164) according to whether in-stent restenosis occurred 1 year after PCI, whose serum miR-647 and PTEN levels were measured by qPCR and ELISA. Pearson correlation was used to analyze the correlation between serum miR-647 and PTEN levels in ACS patients, multifactor Logistic regression to analyze the factors influencing in-stent restenosis after PCI in ACS patients, and ROC to analyze the predictive value of serum miR-647 and PTEN levels on in-stent restenosis after PCI in ACS patients.Results: Compared with the non-restenosis group, miR-647 levels increased and PTEN levels decreased in the restenosis group (P＜0.05). Serum miR-647 in ACS patients was negatively correlated with PTEN levels (r=-0.701, P＜0.001). Stent internal diameter, Gensini integral and PTEN were independent protective factors for in-stent restenosis after PCI, and miR-647 was an independent risk factor (P＜0.05). The AUCs for predicting in-stent restenosis after PCI were 0.768, 0.790 and 0.866 for serum miR-647 and PTEN levels at optimal cut-off values of 0.91 and 2.53 ng/mL, respectively, with sensitivities of 66.67%, 64.44% and 77.78% and specificities of 72.56%, 81.10% and 83.54%. miR-647＋PTEN predicted greater AUC than miR-647 for in-stent restenosis after PCI in ACS patients and PTEN alone (P＜0.05).Conclusion: Serum miR-647 levels are elevated and PTEN levels are decreased in ACS patients with in-stent restenosis after PCI, both of which may be jointly involved in in-stent restenosis and can be used as a predictor of in-stent restenosis.
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2022, Vol. 28 
