急性颅脑损伤患者血清中HMGB1 Fas表达水平与术后迟发性颅内血肿的关系

doi:10.3969/j.issn.1006-6233.2022.04.019

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Abstract Objective: To investigate the relationship betweenserum levels of high mobility group box 1 (HMGB1) and Fas and postoperative delayed traumatic intracranial hematoma (DTIH) in patients with acute craniocerebral injury. Methods: A total of 181 patients with acute craniocerebral injury admitted to the hospital between December 2018 and December 2020 were selected as the research subjects. According to postoperative CT examination results, the patients enrolled were divided into DTIH group (n=92) and non-DTIH group (n=89). Postoperative serum levels of HMGB1 and Fas, and other clinical data were compared between the two groups. The relationship between serum levels of HMGB1 and Fas and DTIH was analyzed using Logistic regression model.Results: There were statistically significant differences in serum HMGB1 and Fas between the two groups (P<0.05). The Glasgow Coma Scale (GCS) score of DTIH group was lower than that of the non-DTIH group (P<0.05), and and thrombin time (TT) was longer than that of the non-DTIH group (P<0.05). Logistic regression analysis showed that serum HMGB1, Fas, TTand GCS scorewere influencing factors of postoperative DTIH in patients with acute craniocerebral injury (P<0.05).Conclusion: The occurrence of DTIH in patients with acute craniocerebral injury may be related to serum HMGB1 and Fas. Clinical monitoring of related factors can provide an effective basis for disease diagnosis, treatment and prevention.

Key words： Acute craniocerebral injury Delayed traumatic intracranial hematoma Serum high mobility group box 1 Fas

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	WANG Yuyue
	FAN Yunfei
	YANG Xiaokun
	et al

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WANG Yuyue,FAN Yunfei,YANG Xiaokun, et al. Relationship Between HMGB1 and Fas Expression Levels in Serum ofPatients with Acute Craniocerebral Injury and Postoperative Delayed Intracranial Hematoma[J]. HeBei Med, 2022, 28(4): 624-627.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.04.019 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I4/624

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