NF-κB PAI-1 血沉在川崎病并发冠状动脉损伤诊断及病情评估中的应用价值

doi:10.3969/j.issn.1006-6233.2022.04.013

Abstract
Figure/Table
References
Related Citation (8)

Download: PDF (1498 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To explore the application of nuclear factor kappa B (NF-κB), tissue-type plasminogen activator inhibitor-1 (PAI-1), and erythrocyte sedimentation rate (ESR) in the diagnosis and evaluation of coronary artery injury complicated by Kawasaki disease. Methods: A total of 245 children with Kawasaki disease in our hospital from May 2017 to April 2021 were selected as the research subjects. According to the results of coronary ultrasound examination, they were divided into observation group (complicated by coronary artery injury, n=42) and control group (without coronary artery injury, n=203). The clinical data, NF-κB, PAI-1, and ESR levels of the two groups were compared, the factors affecting the incidence of Kawasaki disease complicated by coronary artery injury were analyzed, the receiver operating curve (ROC) was plotted, and the level of NF-κB, PAI-1, and ESR was evaluated. And then the levels of NF-κB, PAI-1 and ESR in children with different degrees of coronary artery dilation were compared, and the relationship between the levels of NF-κB, PAI-1, ESR and the degree of coronary artery dilation was analyzed. Results: The proportion of male in the observation group, platelet count, starting time of intravenous immunoglobulin, duration of fever, NF-κB, PAI-1, and ESR levels were higher than those in the control group (P<0.05); Logistic regression analysis showed that male, platelet count, starting time of intravenous immunoglobulin, duration of fever, NF-κB, PAI-1, and ESR levels are all independent factors influencing the onset of Kawasaki disease complicated by coronary artery injury (P<0.05); Kawasaki disease complicated by coronary artery injury is a positive sample, and non-complicated coronary artery injury is a negative sample. The ROC curve of the diagnostic value of NF-κB, PAI-1, and ESR levels to Kawasaki disease complicated by coronary artery injury was plotted. The results showed that the AUCs of the diagnostic value of NF-κB, PAI- 1, ESR level for Kawasaki disease complicated by coronary artery injury were 0.814, 0.656, 0.726, respectively. Logistic binary regression fitting was used to construct the AUC of each index combined diagnosis. The results showed that the combined AUC of each index was 0.882 . With the increase of coronary artery dilation, the levels of NF-κB, PAI-1, and ESR in children increased significantly, and the difference was statistically significant (P<0.05). There is a positive correlation between the levels of NF-κB, PAI and ESR in children with Kawasaki disease complicated by coronary artery injury and the degree of coronary artery dilation (P<0.05). Conclusion: The levels of NF-κB, PAI-1 and ESR in children with Kawasaki disease complicated by coronary artery injury are significantly increased, and are positively correlated with the degree of coronary artery dilation. Clinical detection of their levels is helpful for early diagnosis and evaluation of the disease. It provides clinical basis for diagnosis and treatment.

Key words： Kawasaki disease Coronary artery injury NF-κB PAI-1 ESR

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Zhihai

Cite this article:

WANG Zhihai. The Application Value of NF-κB PAI-1 and Erythrocyte Sedimentation Rate in Diagnosis and Evaluation of Coronary Artery Injury Complicated by Kawasaki Disease[J]. HeBei Med, 2022, 28(4): 594-598.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.04.013 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I4/594

[1] Noval Rivas M,Arditi M.Kawasaki disease:pathophysiology and insights from mouse models[J].Nat Rev Rheumatol,2020,16(7):391~405.
[2] 郭璇,宋瑶,阿布来提·阿不都哈尔.肺炎支原体感染合并川崎病患儿血清IL-6,IL-8及IL-10水平与冠状动脉损伤的相关性[J].分子诊断与治疗杂志,2020,12(8):1069~1072,1094.
[3] Noval Rivas M,Arditi M.Kawasaki disease:pathophysiology and insights from mouse models[J].Nat Rev Rheumatol,2020,16(7):391~405.
[4] 文一州,王献民,郭永宏,等.基于Z值的川崎病并发冠状动脉损伤危险因素分析[J].重庆医学,2019,48(9):1579~1582.
[5] 余淋,陈明群,徐敏.川崎病并发冠脉损伤患儿血清PAI-1水平对血管内皮细胞活力的影响[J].河北医学,2018,24(11):1761-1765.
[6] Lavery L A,Ahn J,Ryan E C,et al.What are the optimal cutoff values for ESR and CRP to diagnose osteomyelitis in patients with diabetes-related foot infections[J].Clin Orthop Relat Res,2019,477(7):1594~1602.
[7] Walter C E J,Durairajan S,Periyandavan K,et al.Bladder neoplasms and NF-κB:an unfathomed association[J].Expert Rev Mol Diagn,2020,20(5):497~508.
[8] 王志群,张雁,宋宁,等.川崎病合并冠状动脉损伤患儿血清同型半胱氨酸,N末端B型利钠肽前体,缺血修饰白蛋白水平变化及意义[J].中国临床医生杂志,2021,49(7):859~862.
[9] 王卫平.儿科学[M].第8版.北京:人民卫生出版社,2013.192~194.
[10] Jones V G,Mills M,Suarez D,et al.COVID-19 and kawasaki disease:novel virus and novel case[J].Hosp Pediatr,2020,10(6):537~540.
[11] 刘晓华,刘霞,金路,等.川崎病患儿血浆中可溶性内皮细胞蛋白C受体、一氧化氮的表达及与炎症反应和冠状动脉病变的关系[J].现代生物医学进展,2019,19(2):326~329.
[12] Kunnumakkara A B,Shabnam B,Girisa S,et al.Inflammation,NF-κB,and chronic diseases:how are they linked[J].Crit Rev Immunol,2020,40(1):1~39.
[13] Li X,Wu Y,Song Y,et al.Activation of NF-κB-inducing kinase in islet β cells causes β cell failure and diabetes[J].Mol Ther,2020,28(11):2430~2441.
[14] Gao Y,Jin H.Plasminogen activator inhibitor-1:a potential etiological role in livedoid vasculopathy[J].Int Wound,2020,17(6):1902~1908.
[15] Revel M P,Parkar A P,Prosch H,et al.COVID-19 patients and the radiology department - advice from the european society of radiology (ESR) and the european society of thoracic imaging (ESTI)[J].Eur Radiol,2020,30(9):4903~4909.