低分子肝素联合阿司匹林治疗妊娠期高血压对氧化应激子宫动脉血流TEG参数及妊娠结局的影响

doi:10.3969/j.issn.1006-6233.2022.03.032

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Abstract Objective: To explore the effect of low molecular heparin combined with aspirin in the treatment of pregnancy-induced hypertension on oxidative stress, uterine artery blood flow, TEG parameters and pregnancy outcome. Methods: A total of 126 patients with pregnancy-induced hypertension admitted between February 2019 and February 2021 were divided into 2 groups using a simple randomized grouping method, 64 in the control group were treated with conventional medication and 62 in the observation group were treated with low molecular heparin combined with aspirin, and the two groups were compared for TEG parameters, uterine artery blood flow, oxidative stress, and pregnancy outcome after treatment. Results: The R (6.95±1.22) min, K (2.15±0.11) min and α-Angle (72.12±4.63)°and MA (66.96 ± 3.32) mm parameters in the observation group was better than in the control group (P<0.05), and the stability of LPO, GSH-Px, Hcy, SOD, PI, RI and S/D in the observation group was better than in the control group (P<0.05). At the same time, in the observation group, 12.90% cesarean delivery, 3.23% postpartum haemorrhage, 1.61% placental abruption, 0.00% neonatal asphyxia, 3.23% preterm delivery and 1.61% fetal distress rate were lower than the control group with 32.81% cesarean delivery, 18.75% postpartum haemorrhage, 10.94% placental abruption, 9.38% neonatal asphyxia, 15.63% preterm delivery and 12.50% fetal distress rate (P<0.05). Conclusion: The treatment of low molecular heparin combined with aspirin in patients with pregnancy-induced hypertension can improve the oxidative stress response, stabilize the uterine artery blood flow, and reduce the occurrence of adverse pregnancy outcomes.

Key words： Pregnancy-induced hypertension Low molecular heparin Aspirin Uterine artery blood flow Oxidative stress Pregnancy outcome

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	XIAO Jin
	DU Yun
	HE Tongqiang
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Cite this article:

XIAO Jin,DU Yun,HE Tongqiang, et al. Effects of Low Molecular Heparin Combined with Aspirin on Oxidative Stress, Uterine Artery Blood Flow TEG Parameters and Pregnancy Outcome in the Treatment of Pregnancy-Induced Hypertension[J]. HeBei Med, 2022, 28(3): 503-507.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.03.032 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I3/503

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