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| Correlation of Abnormal IgA1 Molecular Glycosylation with Th17 Cells in Patients with IgA Nephropathy |
| HOU Jing, et al |
| The Affiliated Hospital of Southwest Medical University, Sichuan Luzhou 646000, China |
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Abstract Objective: To investigate the correlation between abnormal glycosylation of IgA1 molecule and Th17 cells in patients with IgA nephropathy. Methods: The clinical data of 50 patients with IgA nephropathy (IgA nephropathy group) and 50 healthy people (healthy control group) were selected for retrospective analysis. The patients’ admission period was from February 2018 to May 2020. Th17 cells, Treg cells, Gd-IgA1, TGF-β, IL-6, IL-17, IL-21, IL-23, serum creatinine, albumin and urine protein quantification were compared; Pearson method was used to analyze Gd-IgA1 and Th17 correlation of cells, Treg cells, and correlation of cytokines with Gd-IgA1. Results: Th17 cells, Th17/Treg, Gd-IgA1, IL-6, IL-17, IL-21, IL-23, serum creatinine and urine protein in the IgA nephropathy group were all higher than those in the healthy control group, while Treg cells, TGF-β and albumin were lower than the healthy control group (P＜0.05). Pearson correlation showed that Gd-IgA1 was positively correlated with Th17 cells and Th17/Treg (r=0.737/0.810, P＜0.05), and negatively correlated with Treg cells (r=-0.487, P＜0.05). Gd-IgA1 was negatively correlated with TGF-β (r=-0.260, P＜0.05), and positively correlated with IL-6, IL-17, IL-21, and IL-23 (r=0.796/0.776/0.714/0.819, P<0.05). Conclusion: In patients with IgA nephropathy, Th17 cells are positively correlated with Gd-IgA1, and the expression of Th17 cells can be evaluated to provide a basis for clinical diagnosis and treatment.
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[1] 黄海,列才华,梁兰青,等.细胞因子对IgA肾病患者IgA1 O-糖基化的影响及相关机制研究[J].东南国防医药,2019,21(1):44~48.
[2] 贾慧宇,程光慧.Th17细胞与Treg细胞及相关细胞因子在SLE患者外周血中的表达及意义[J].河北医学,2018,24(8):1277~1281.
[3] 章哪哪,李本农,许伟民,等.OSAHS患者外周血Th17细胞相关细胞因子的表达及临床意义[J].华中科技大学学报(医学版),2020,49(5):587~590.
[4] 中华医学会儿科学分会肾脏学组.原发性IgA肾病诊治循证指南(2016)[J].中华儿科杂志,2017,55(9):643~646.
[5] 宋轻雷,刘颖,刘乃全,等.血清异常糖基化IgA1在40例IgA肾病诊断中的应用价值研究[J].中国实用内科杂志,2019,39(3):270~273.
[6] 刘书馨,刘红,陈琛,等.IgA肾病患者血清IgA1异常糖基化与氧化应激关系的研究[J].中国医师进修杂志,2018,41(1):5~9.
[7] 李团团.血清IgA、IgA/C3和IgA/C4比值在IgA型肾病临床鉴别诊断中的应用[J].蚌埠医学院学报,2018,43(5):642~644.
[8] 彭思琪,卢文,江肖,等.742例原发性IgA肾病患者的临床病理特征及其预后分析[J].中华肾脏病杂志,2021,37(2):87~94.
[9] Wide L,Eriksson K.Unique pattern of N-glycosylation,sialylation,and sulfonation on TSH molecules in serum of children up to 18 months[J].Clin Endocrinol Metab,2019,104(10):4651~4659. |
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2022, Vol. 28 
