|
|
Efficacy of High-Intensity Focused Ultrasound Ablation in the Treatment of Uterine Fibroids and Its Influence on Levels of Serum VEGF and ER and Pregnancy Outcomes |
FAN Jingchun, JI Yanqin |
Huizhou Central People's Hospital, Guangdong Huizhou 516001, China |
|
|
Abstract Objective: To study the efficacy of high-intensity focused ultrasound ablation on uterine fibroids and its influence on levels of serum vascular endothelial growth factor (VEGF) and estrogen receptor (ER) and pregnancy outcomes. Methods: Totally 121 patients with uterine fibroids of childbearing age admitted to the hospital from January 2019 to September 2020 were selected as the research subjects, and they were divided into control group (n=61) and observation group (n=60) according to the medical advices, progression of disease and patients’ desires. The control group was treated with conventional conservative drugs, and the observation group underwent high-intensity focused ultrasound ablation. The efficacy, uterine volume and uterine fibroids volume, levels of serum VEGF, ER and estradiol (E2) and postoperative pregnancy were compared between the two groups after treatment. Results: Before implementing the corresponding treatments, there were no significant differences in the uterine volume, uterine fibroids volume and levels of serum VEGF, ER and E2 between the two groups (P>0.05). After treatment, the uterine volume, uterine fibroids volume and levels of serum VEGF, ER and E2 were decreased in the two groups, and the difference of the above indexes in the observation group before and after treatment was significantly greater than that in the control group (P<0.05). After treatment, the efficacy and postoperative pregnancy of observation group were better than those of control group (P<0.05). Conclusion: High-intensity focused ultrasound ablation has a significant efficacy on uterine fibroids. It can reduce the levels of serum VEGF and ER and the volume of uterus andvolume of uterine fibroids, and it has a significant effect and the pregnancy outcomes of observation group are better than control group. Thus this kind of treatment method has clinical promotion value.
|
|
|
|
|
[1] 王罕瑾,蒋本贵.经阴道与经脐单孔腹腔镜在子宫肌瘤手术中的应用比较[J].中国内镜杂志,2020,26(12):60~65. [2] 曹双双,陈世超,解丹,等.MicroRNA-182和microRNA-152在早期子宫内膜癌组织中的差异性表达[J].中国生育健康杂志,2020,31(3):266~269. [3] 林琳,牛华,任红莲.腹腔镜与开腹手术治疗子宫肌瘤患者的疗效对比及对免疫功能的影响[J].贵州医药,2021,45(1):67~68. [4] 尤俊芬.高强度聚焦超声消融术治疗不同大小子宫肌瘤的疗效及对患者妊娠结局的影响[J].实用癌症杂志,2020,35(4):656~659. [5] 李平,向玲,李琳.高强度聚焦超声子宫肌瘤消融术与腹腔镜子宫肌瘤剔除术后患者妊娠情况比较[J].中国医学装备,2018,15(3):59~62. [6] 张骞,汤蓓,张玲,等.CT与超声在子宫肌瘤诊断价值对照研究及影像表现分析[J].中国CT和MRI杂志,2020,18(1):108~110. [7] 姚一静,姜立新.超声影像方法在预测HIFU治疗子宫肌瘤疗效中的应用[J].声学技术,2021,40(3):376~380. [8] 石梅,杨友莲,敖登其其格.育龄、绝经过渡期子宫肌瘤患者子宫内膜病理改变分析[J].中国妇幼保健,2020,35(14):2578~2580. [9] 朱俊,吴琼.子宫肌瘤不同治疗方式的妊娠结局及妊娠后复发的观察[J].西南国防医药,2018,28(12):1241~1243. [10] 周芳露,吕富荣,吕发金,等.术前DTI纤维束示踪成像定量参数与高强度聚焦超声消融子宫肌瘤疗效的相关性研究[J].临床放射学杂志,2020,39(1):206~211. [11] 俞佳丽,朱鸣萍,赵文龙,等.宫瘤宁胶囊联合米非司酮对子宫肌瘤患者的临床疗效[J].中成药,2020,42(1):94~96. [12] 陈剑,施斌.理气消癥汤联合米非司酮、他莫昔芬治疗子宫肌瘤的临床观察[J].中国中医药科技,2021,28(3):437~439. |
|
|
|