血清PTX3水平在急性脑梗死患者动态变化与远隔缺血后神经保护的相关性分析

doi:10.3969/j.issn.1006-6233.2022.03.014

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Abstract Objective: To study the correlation between dynamic changes of serum pentraxin 3 (PTX3) and neuroprotection after remote ischemia in patients with acute cerebral infarction (ACI). Methods: A total of 150 patients with ACI treated in the hospital between June 2019 and June 2021 were enrolled and divided into experimental group and control group by simple random grouping method, 75 cases in each group. The control group was given standardized treatment, while the experimental group was given ischemic preconditioning treatment on the basis of the control group. The level of serum PTX3 was compared between the two groups. The nerve function was assessed by NIHSS score, and its correlation with serum PTX3 was analyzed. At 90d after treatment, short-term prognosis was assessed by mRS score and BartheI index. The prognosis between the two groups was compared. The correlation between serum PTX3 and prognosis and its predictive value for prognosis were analyzed. Results: After treatment, level of serum PTX3 and NIHSS score in both groups were significantly decreased, which were lower in experimental group than in control group at 7d and 14d after treatment (P<0.05). After treatment, the experimental group had significantly lower mRS scores, and higher BartheI index than the control group. The changes were greater in the experimental group than in the control group (P<0.05). The level of serum PTX3 was positively correlated with NIHSS and mRS scores, while negatively correlated with BartheI index (P<0.05). The area under the ROC curve (AUC), sensitivity, and specificity of serum PTX3>3.34μg/L to predict the prognosis of patients with ACI were 0.948, 92.86%, and 82.26% (P<0.05). Conclusion: The level of serum PTX3 is significantly correlated with neurological deficits and prognosis in ACI patients, which can be applied to assessing neurological deficits and predict short-term prognosis in ACI patients after RIC.

Key words： Acute cerebral infarction Pentraxin 3 Neuroprotection after remote ischemia Correlation

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.03.014 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I3/417

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