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Effect of Clopidogrel Combined with Butylbenzene Peptide on Serum Levels of VEGF bFGF Ang-1 and Cognitive Function in Patients with Acute Cerebral Infarction |
NIU Xiang, WANG Benxiao, BU Hongwei |
Anhui Wanbei Coal and Electricity Group General Hospital, Anhui Suzhou 234000, China |
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Abstract Objective: To investigate the effect of clopidogrel combined with butylbenzene peptide on serum levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiopoietin-1 (Ang-1) and cognitive function in patients with acute cerebral infarction (ACI). Methods: One hundred and fifty-two patients with ACI admitted to Anhui Wanbei Coal and Electricity Group General Hospital from January 2018 to May 2020 were collected and divided into observation group (n=76) and control group (n=76) with simple random grouping method. Patients in the control group were given routine treatment and clopidogrel. On this basis, patients in observation group were given butylbenzene peptide capsule. The score of National Institutes of Health Stroke Scale (NIHSS), Montreal Cognitive Assessment (MoCA), serum levels of VEGF, bFGF and Ang-1 before and after intervention and the clinical effect were compared between two groups. Results: There were no significant differences in baseline data, NIHSS score, MoCA score, serum levels of VEGF, bFGF and Ang-1 before intervention between the two groups (P>0.05). For intra-group comparison, the NIHSS score at 1 and 3 months after intervention of two groups were apparently lower than those before intervention, and MoCA score, serum levels of VEGF, bFGF and Ang-1 were apparently higher than those before intervention (P<0.05). For inter-group comparison, the NIHSS score in observation group at 1 and 3 months after intervention was apparently lower than that in control group, and the MoCA score, serum levels of VEGF, bFGF and Ang-1 were apparently higher than those in control group (P<0.05). The total efficacy of observation group at 3 months after intervention was apparently higher than that in control group (P<0.05). Conclusion: Clopidogrel combined with butylbenzene peptide could apparently improve the cognitive function of patients with ACI, elevate serum levels of vascular growth related factors such as VEGF, bFGF and Ang-1, whose clinical effect is significant and worthy of clinical application.
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[1] 陈洁.丁苯酞联合不同剂量阿托伐他汀对ICVD病人动脉介入治疗后血流动力学的影响[J].蚌埠医学院学报,2019,44(10):1365~1369. [2] 王琴,孔伟丽,吕康,等.氯吡格雷联合丁苯酞注射液治疗急性脑梗死的效果及对抗氧化能力的影响[J].临床误诊误治,2021,34(4):39~43. [3] 贝筝,陈怡,龙登毅,等.丁苯酞联合依达拉奉治疗急性脑梗死患者神经功能及血管内皮功能的影响[J].脑与神经疾病杂志,2019,27(1):5~9. [4] 赵洁,朴翔宇,吴悦.丁苯酞联合阿替普酶治疗急性缺血性脑卒中的临床效果及对患者血清炎性因子及神经递质水平的影响[J].中国医药,2019,14(4):553~557. [5] 冯丽娜,王宏.不同时间窗阿替普酶在脑梗死患者中的疗效及对认知功能的影响[J].天津医药,2019,47(5):521~524. [6] 胡俊涛,陈国芹,曹凯,等.前列地尔联合丁苯酞对LI合并轻度VCI的疗效及其对患者脑血流灌注、氧化应激和认知功能的影响[J].实用药物与临床,2020,23(4):313~317. [7] 辛茹,刘朝峰.丁苯酞注射液对急性大脑中动脉供血区卒中患者的疗效及对脑血管CO2反应性的影响[J].药物评价研究,2019,42(4):689~692. |
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