甘孜藏区某三甲医院分离细菌分布现状及对常用抗菌药物的耐药性分析

doi:10.3969/j.issn.1006-6233.2022.02.027

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Abstract Objective: To investigate the distribution of bacteria isolation in a grade A hospital in Ganzi Tibetan Prefecture, and analyze the resistance to commonly used antibacterial drugs. Methods: The clinically isolated strains between 2017 and 2020 were collected and analyzed from perspectives of specimen source, detection of bacteria, and drug sensitivity test results. Results: A total of 2,946 non-repetitive strains were isolated, most of which were from ICU, department of gastrointestinal surgery, department of hepatobiliary surgery, department of neurosurgery, department of orthopedics, and department of urology. Gram-positive bacteria and gram-negative bacteria accounted for 31.40% and 68.60%, mainly including Escherichia coli, Klebsiella pneumoniae, and staphylococcus aureus. Escherichia coli and Klebsiella pneumoniae were highly sensitive to carbapenems, and the drug resistance rates of most bacteria were lower than 10%. Staphylococcus aureus and staphylococcus epidermidis were highly resistant to penicillin G, followed by erythromycin. No vancomycin or linezolid-resistant staphylococcus aureus was detected. 1,068 (36.25%) extended-spectrum β-lactamase (ESBLs) strains, 159 (5.40%) strains of methicillin-resistant staphylococcus (MRS), and 248 (8.42%) strains of methicillin-resistant staphylococcus aureus (MRSA), and 2 (0.07%) strains of vancomycin-resistant enterococcus (VRE) were detected. MRS and MRA both were completely resistant to penicillin G and oxacillin, but sensitive to vancomycin, teicoplanin, linezolid, and sulfamethoxazole/trimethoprim. Conclusion: Escherichia coli, Klebsiella pneumoniae, and staphylococcus aureus were main bacteria isolated in a grade A hospitals in Ganzi Tibetan Prefecture from 2017 to 2020. ESBLs. MRS, MRSA and VRE were detected, with drug resistance. Therefore, antibacterial drugs are recommended to be used rationally.

Key words： Grade A hospital Bacterial isolation Investigation Antibacterial drug Drug resistance rate

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	CHEN Shanshan
	DUAN Fengmei
	DANZHEN Zhuoma
	et al

Cite this article:

CHEN Shanshan,DUAN Fengmei,DANZHEN Zhuoma, et al. An Investigation on the Distribution of Bacteria Isolation in a Grade A Hospital in Ganzi Tibetan Prefecture and the Resistance to Antibacterial Drugs in Common Use[J]. HeBei Med, 2022, 28(2): 308-313.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.02.027 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I2/308

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