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| Relationship of Serum YKL-40 and Irisin Levels with Glucose and Lipid Metabolism and Insulin Resistance in Pregnant Women with Gestational Diabetes Mellitus |
| SONG Jie, et al |
| Hainan General Hospital, Hainan Haikou 570203, China |
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Abstract Objective: To investigate the correlation of serum human cartilage glycoprotein-39 (YKL-40) and irisin levels with glucose and lipid metabolism and insulin resistance (IR) in pregnant women with gestational diabetes mellitus (GDM). Methods: A total of 148 pregnant women with GDM (GDM group) admitted to Hainan Provincial People's Hospital between January 2018 and January 2021were enrolled in this study. Meanwhile, with the gestational age matching principle, 50 healthy pregnant women who received routine examinations in obstetric department of the hospital were selected as the control group. The levels of serum YKL-40, irisin, fasting plasma glucose (FPG), 2 hours postprandial plasma glucose (2hPG), glycosylated hemoglobin (HbAlc), total cholesterol (TC), high/low density lipoprotein cholesterol (H/LDL-C), triglyceride (TG) and fasting insulin (FINS) were compared between the two groups. The insulin resistance index (HOMA-IR) and insulin secretion index (HOMA-B) were calculated. Pearson correlation analysis was performed to test the correlation of serum YKL-40 and irisin with other indicators. Results: Compared with the control group, the GDM group had higher levels of serum YKL-40, FPG, 2hFPG, HbAlc, TC, LDL-C, TG, FINS and HOMA-IR, and lower levels of irisin, HDL-C and HOMA-B (P<0.05). Pearson correlation analysis showed that serum YKL-40 was positively correlated with FPG, 2hFPG, TC, LDL-C, TG, FINS and HOMA-IR, and negatively correlated with HDL-C and HOMA-B (P<0.05). Serum irisin was negatively correlated with FPG,2hFPG, HbAlc, TC, LDL-C, TG, FINS and HOMA-IR, and positively correlated with HDL-C and HOMA-B (P<0.05). Conclusion: Pregnant women with GDM have high serum YKL-40 level and low irisin level. The two are closely related to glucose and lipid metabolism and insulin resistance, with certain clinical value in the diagnosis and treatment of GDM.
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[1] 王笑笑,刘情,张英奎,等.2016年河北省妊娠期糖尿病患病率和流行病学特点分析[J].中国全科医学,2018,21(21):2592~2596.
[2] Johns EC,Denison FC,Norman JE,et al.Gestational diabetes mellitus:mechanisms,treatment,and complications[J].Trends Endocrinol Metab,2018,29(11):743~754.
[3] 毋江波,张勇.Irisin与疾病关系的研究进展[J].生理科学进展,2018,49(6):67~72.
[4] 宋鸿碧,徐飏,曹婷,等.二甲双胍联合胰岛素泵治疗妊娠期糖尿病及对血清YKL-40、Irisin水平的影响[J].中国现代医学杂志,2018,28(34):54~59.
[5] Dugan JA,Ma Crawford J.Managing gestational diabetes[J].JAAPA,2019,32(9):21~25.
[6] Metzger BE,Coustan DR,Trimble ER.Hyperglycemia and adverse pregnancy outcomes[J].Clin Chem,2019,65(7):937~938.
[7] Ramel S,Rao R.Hyperglycemia in Extremely Preterm Infants[J].Neoreviews,2020,21(2):89~97.
[8] 刘海蔚,陈道雄,陈开宁,等.肥胖2型糖尿病患者血清几丁质酶3样蛋白1水平与胰岛素抵抗指数及糖化血红蛋白关系的研究[J].中国糖尿病杂志,2019,27(12):900~902.
[9] 谭致君.肌肉因子Irisin多效性研究进展[J].山东医药,2020,60(17):101~104.
[10] 朱翠松,杨瑜,刘明斌,等.脂肪组织巨噬细胞在肥胖诱导的炎症和胰岛素抵抗中的作用[J].复旦学报(医学版),2019,266(5):117~122.
[11] Bousmpoula A,Benidis E,Demeridou S,et al.Serum and follicular fluid irisin levels in women with polycystic ovaries undergoing ovarian stimulation:correlation with insulin resistance and lipoprotein lipid profiles[J].Gynecol Endocrinol,2019,35(9):803~806. |
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2022, Vol. 28 
