连续性肾脏替代疗法叠加全血吸附治疗脓毒性休克对患者肾功能血清TLR4 cTnI水平的影响

doi:10.3969/j.issn.1006-6233.2022.02.012

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Abstract Objective: To observe the effects of continuous renal replacement therapy (CRRT) combined with hemadsorption on renal function and levels of serum Toll-like receptor 4 (TLR4) and cardiac troponin I (cTnI) in the treatment of septic shock. Methods: A total of 139 patients with septic shock treated in the hospital between October 2018 and October 2020 were selected as the research subjects, and they were divided into control group (69 cases) and observation group (70 cases) according to the stratified randomization of the random number table method. The control group was given conventional treatment, and the observation group was given CRRT combined with hemadsorption on the basis of conventional treatment. The perioperative basic status (shock duration, ambulation time, hospital stay) were compared between the two groups, and the renal function [serum cystatin C (cysC), neutrophil gelatinase-associated lipocalin (NGAL)], immune function [TLR4, nuclear factor-κB (NF-κB)] and myocardial function [cTnI, creatine kinase isoenzyme MB (CK-MB)] of the two groups of patients were compared before treatment and 1 week after treatment. Results: The shock duration, ambulation time and hospital stay in observation group were significantly shorter than those in control group (P<0.05). 1 week after treatment, the levels of cysC, NGAL, TLR4, NF-κB, cTnI and CK-MB in the two groups were significantly decreased compared with those before treatment (P<0.05), and the decrease ranges of cysC, NGAL and NF-κB in observation group were significantly higher than those in the control group (P<0.05). Conclusion: CRRT combined with hemadsorption has a significant efficacy on patients with septic shock, and it can effectively improve the renal function, remove the inflammatory mediators, and reduce the levels of serum TLR4 and cTnI, with high clinical application value.

Key words： Continuous renal replacement therapy Hemadsorption Septic shock Renal function Serum Toll-like receptor 4 Cardiac troponin I

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Cite this article:

LI Yan. Effects of Continuous Renal Replacement Therapy Combined with Hemadsorption on Renal Function and Levels of Serum TLR4 and CTnI in Treating Septic Shock[J]. HeBei Med, 2022, 28(2): 240-244.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.02.012 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I2/240