腋窝淋巴结转移的三阴性乳腺癌组织中C-erbB-2 NuSAP1表达及意义分析

doi:10.3969/j.issn.1006-6233.2022.02.011

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Abstract Objective: To investigate the expression of epidermal growth factor receptor 2 (C-erbB-2) and nuclear spindle associated protein 1 (NuSAP1) in tumor tissues and paracancer tissues of triple negative breast cancer patients with axillary lymph node metastasis and to analyze their significance. Methods: Clinical data of 150 breast cancer patients treated in our hospital from July 2016 to October 2020 were retrospectively selected, and the patients were divided into observation group (triple negative breast cancer) and control group (non triple negative breast cancer) according to immunohistochemistry, with 49 cases in observation group and 101 cases in control group. The expression levels of C-erbB-2 and NuSAP1 were compared between the two groups, and their relationship with axillary lymph node metastasis was analyzed. Results: The high expression rate of C-erbB-2 in observation group was 87.76%, which was significantly higher than that in control group (63.37%) (P<0.05). The positive high expression rate of NuSAP1 in observation group was 79.59%, which was significantly higher than that in control group (61.39%) (P<0.05). Among the 49 patients with triple negative breast cancer, 22 had no axillary lymph node metastasis and 27 had axillary lymph node metastasis. The axillary lymph node metastasis rate of c-erbB-2 and NuSAP1 high expression group was significantly higher than that of low expression group (P<0.05). Conclusion: The positive overexpression rate of C-erbB-2 and NuSAP1 in triple negative breast cancer is higher than that in non triple negative breast cancer, and the positive overexpression rate of C-erbB-2 and NuSAP1 in axillary lymph node metastasis is significantly higher than that in non-axillary lymph node metastasis, which may be a new prognostic indicator.

Key words： Lymph node metastasis Triple negative breast cancer Epidermal growth factor receptor 2 Nucleolar spindle associated protein 1

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.02.011 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I2/236

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