辅酶Q10联合果糖二磷酸钠或磷酸肌酸钠治疗小儿病毒性心肌炎对心肌酶谱及免疫功能的影响

doi:10.3969/j.issn.1006-6233.2022.01.035

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Abstract Objective: To explore the effect of coenzyme Q10 combined with fructose sodium diphosphate or sodium phosphate in the treatment of myocardial spectrum and immune function of viral myocarditis. Methods: A total of 270 children with viral myocarditis admitted from November 2019 to November 2020 were selected as the subjects and divided into control group (142 cases, administered coenzyme Q10 fructose sodium diphosphate and sodium fructose diphosphate) and study group (128 cases, administered coenzyme Q10 fructose sodium diphosphate and sodium creatine phosphate). The therapeutic efficacy, myocardial enzyme spectrum (serum CK-MB、CPK、cTnI、HBDH、LDH) and immune function (CD3⁺、CD4⁺、CD4⁺/CD8⁺) were compared between the two groups. Results: The total effective rate of 1, 2 and 3 weeks treatment in the study group was higher than that in the control group, and the difference was statistically significant (Wald χ² group =7.412, Wald χ² time point =290.769, P group =0.006, P time point<0.001). Before treatment, there was no significant difference in the values of CK-MB, CPK, cTnI, HBDH, LDH, LVEF, FS, CI, CD3⁺, CD4⁺, CD4⁺/CD8⁺ between the two groups (P>0.05); After treatment, the levels of CK-MB, CPK, cTnI, HBDH and LDH in the study group were lower than those in the control group (P<0.05), LVEF, FS, CI, CD3+, CD4+, CD4+/CD8+ were higher than those in control group (P<0.05); The difference of CK-MB, CPK, cTnI, HBDH, LDH, LVEF, FS, CI, CD3⁺, CD4⁺, CD4⁺/CD8⁺ between the two groups before and after treatment was statistically significant (P<0.05).Conclusion: The effect of coenzyme Q10 combined with sodium phosphate in the treatment of viral myocarditis in children is better than that of coenzyme Q10 combined with sodium fructose diphosphate, which can effectively improve the myocardial enzyme spectrum and improve the immunity of children.

Key words： Viral myocarditis Coenzyme Q10 Sodium fructose diphosphate Sodium creatine phosphate

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	Articles by authors
	ZHANG Yaning
	YUAN Zhanwang
	GUO Yapeng

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ZHANG Yaning,YUAN Zhanwang,GUO Yapeng. Effect of Coenzyme Q10 Combined with Sodium Fructose Diphosphate or Sodium Creatine Phosphate on Myocardial Enzyme Spectrum and Immune Function in Children with Viral Myocarditis[J]. HeBei Med, 2022, 28(1): 168-172.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.01.035 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I1/168

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