无水乙醇介入栓塞治疗对脑动静脉畸形患儿神经功能的影响

doi:10.3969/j.issn.1006-6233.2022.01.021

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Abstract Objective: To explore the effects of absolute ethanol interventional embolization under total cerebral angiography and minimally invasive craniotomy on neurological function of children with cerebral arteriovenous malformation (bAVM). Methods: A prospective study was conducted on 62 children with bAVM in our hospital from December 2018 to December 2020. The patients were divided into embolization group (n=31) and craniotomy group (n=31) with the random number table. The craniotomy group was treated with minimally invasive craniotomy, and the embolization group was treated with absolute ethanol intervention embolization under total cerebral angiography. The two groups were compared on cure rate, complications, NIHSS score, serum neurological function indexes [brain-derived neurotrophic factor (BDNF), EF hand-calcineurin (S100B protein), neuron-specific enolase (NSE)], matrix metalloproteinase-9 (MMP-9), tissue matrix metalloproteinase inhibitor-1 (TIMP-1) levels before operation, 7 days after operation, and 1 month after operation. Prognosis 6 months after surgery was compared as well. Results: Re-examination of DSA 1 month after operation showed that both groups of malformations disappeared completely, and the cure rate was 100%. There was no statistically significant difference in the incidence of complications between the two groups (P>0.05). The NIHSS score of the embolization group was lower than that of the craniotomy group 7 days after the operation (P<0.05), there was no statistically significant difference in NIHSS scores between the two groups at 1 month after operation (P>0.05). The level of serum BDNF in the embolization group was higher than that in the craniotomy group at 7 days postoperatively, and the levels of serum S100B protein, NSE, MMP-9 and TIMP-1 were lower than those in the preoperative and craniotomy groups (P<0.05). There were no significant difference in the levels of serum BDNF, S100B protein, NSE, MMP-9 and TIMP-1 between the two groups at 1 month after operation (P>0.05); there was no statistically significant difference in the prognosis of the two groups (P>0.05). Conclusion: Interventional embolization with absolute ethanol under total cerebral angiography for the treatment of bAVM in children can achieve comparable results in minimally invasive craniotomy, and the security is acceptable, Interventional embolization with absolute ethanol can improve the local pathological environment early and avoid brain tissue damage caused by craniotomy, which is conducive to early recovery of nerve function.

Key words： Total cerebral angiography Absolute ethanol Interventional embolization Minimally invasive craniotomy Cerebral arteriovenous malformations

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	HE Shuangshuang
	JI Li
	SUN Yanning

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HE Shuangshuang,JI Li,SUN Yanning. Effect of Absolute Ethanol Interventional Embolization Under Total Cerebral Angiography and Minimally Invasive Craniotomy on Neurological Function of Children with Cerebral Arteriovenous Malformation[J]. HeBei Med, 2022, 28(1): 102-106.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.01.021 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I1/102

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