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| The Diagnostic Value of Serum Amyloid A, Retinol Binding Protein and Urine β2 Microglobulin in Early Renal Injury During Pregnancy Hypertension |
| SHU Yinzhen, QUAN Hui, ZENG Zhirong, et al |
| The Second Affiliated Hospital of Chengdu Medical College / China National Nuclear Corporation 416 Hospital, Sichuan Chengdu 610051, China |
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Abstract Objective: To analyze the diagnostic value of serum amyloid protein A (SAA), retinol binding protein (RBP) and urine beta 2 microglobulin (β2-MG) in early renal injury during pregnancy hypertension disease (HDP). Methods: 120 HDP patients with gestational age of 20~40 weeks in our hospital from March 2019 to March 2021 were selected and divided into mild group (32 cases), moderate group (53 cases) and severe group (35 cases) according to the severity of the disease. In addition, 50 normal pregnant women hospitalized in the same period were selected as the control group. 3 ml of fasting elbow venous blood and 5 ml of midstream urine were collected in the morning. 24 h urine was collected after bladder emptying. The levels of SAA, RBP and urine were compared among the four groups. Receiver operating characteristic curve (ROC) was used to analyze the diagnostic value of each index for early renal injury of HDP. Results: Serum SAA, RBP and urine β2-MG averages increased gradually in the control group, mild group, moderate group, and severe group, and the differences between any two groups were statistically significant (P<0.05). There was a positive correlation between serum SAA, RBP, or urine β2-MG and 24h urinary protein level (r=0.751、0.878、0.668,P<0.05). The combined detection of serum SAA, RBP and urine β2-MG had an ROC curve area (AUC) of 0.918, a sensitivity of 0.895 and a specificity of 0.933 to predict HDP. Conclusion: Serum SAA, RBP and urine β2-MG levels can reflect the degree of kidney damage in HDP patients to a certain extent. Joint testing can improve the sensitivity and specificity of early kidney damage diagnosis in HDP patients, and it has great value for the diagnosis and assessment of the early kidney damage in HDP patients.
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2022, Vol. 28 
