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| The Clinical Significance of the Detection of Peripheral Blood CD64 Index and Serum Amyloid A in the Diagnosis of Bacterial Infection in Preschool Children |
| QU Xiaowei, et al |
| The Affiliated Hospital of Yan'an University, Shaanxi Yan'an 716000, China |
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Abstract Objective: To study the clinical significance of peripheral blood CD64 index and serum amyloid A (SAA) detection in the diagnosis of bacterial infections in preschool children. Methods: With the retrospective analysis method, 200 preschool children with infectious diseases admitted from January 2018 to January 2020 were selected as the research subjects. According to different pathogens, they were divided into children with viral infections (virus group, n=100) and children with bacterial infections(bacterial group, n=100); at the same time, healthy children who were admitted to the hospital for physical examination during the same period were selected as the research subjects as the healthy group (n=100). Comparison was conducted on the CD64 index, SAA level and positive rate of the three groups of subjects, the CD64 index and SAA level before and after antibiotic treatment in the bacterial group, and the efficacy of CD64 and SAA in the diagnosis of bacterial infections was analyzed. Results: The CD64 index and SAA level of the bacterial group were significantly higher, and the difference was significant (P<0.05); compared with the healthy group, the SAA level of the virus group was significantly higher, and the difference was significant (P<0.05) . The CD64 index and SAA levels of children in the bacterial group were significantly lower than those before treatment, and the difference was significant (P<0.05). Compared with the virus group and the healthy group, the bacterial group had a significantly higher CD64 index and SAA positive rate, and the difference was significant (P<0.016); compared with the healthy group, the virus group had a significantly higher SAA positive rate, and the difference was significant (P<0.016). The specificity and positive predictive value of CD64 index in the diagnosis of bacterial infection were significantly higher than SAA, and the difference was significant (P<0.05). Conclusion: CD64 index and SAA test have important clinical value in the diagnosis and evaluation of bacterial infection in preschool children, and CD64 index is more valuable in the diagnosis.
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[1] 高策.血清淀粉样蛋白A联合超敏-C反应蛋白检测在感染性疾病患儿鉴别诊断中的价值分析[J].现代诊断与治疗,2020,31(20):3300~3302.
[2] 田梅,陈启斌,李雪梅,等.C-反应蛋白、血清淀粉样蛋白A和YKL-40在小儿复发性肺炎中的联合检测作用[J].标记免疫分析与临床,2018,13(1):69~72,77.
[3] 张锡波,叶旭鑫,何慧君,等.学龄前儿童细菌性腹泻的病原学特征及PCT、CD64和s TREM-1测定的临床意义[J].现代生物医学进展,2020,20(8):1506~1510.
[4] 温成波,罗标,刘琼章,等.SAA、hs-CRP、NLR检测对儿童呼吸道感染的诊断价值[J].深圳中西医结合杂志,2019,29(10):76~78.
[5] 杜长宝,杨婷,郑晓燕.CD64和降钙素原检测在学龄前儿童感染性腹泻中的鉴别诊断价值[J].中国卫生检验杂志,2019,29(4):448~450.
[6] 戴金肖,张媛媛,张金飞.CD64指数和血清淀粉样蛋白A检测在学龄前儿童细菌感染诊断和鉴别诊断中的意义[J].中国卫生检验杂志,2019,29(7):835~837.
[7] 吴金斌,邹德学,周逵,等.降钙素原与淀粉样蛋白A检测在学龄前儿童早期细菌感染中的诊断价值[J].国际检验医学杂志,2019,37(15):2126~2128. |
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2021, Vol. 27 
