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| The Value of CLEC-2 in Peripheral Blood in Predicting the Death Risk of Patients with Traumatic Brain Injury |
| LI Fang, TANG Shijun, DU Wei, et al |
| Xinjiang Uygur Autonomous Region People's Hospital, Xinjiang Urumqi 830001, China |
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Abstract Objective: To investigate the value of peripheral blood C-type leetin-like receptor-2 (CLEC-2) levels in early prediction of the 30-day risk of death in patients with traumatic brain injury. Methods: 113 patients with TBI were included in from March 2018 to January 2020. The clinical data of the patients were collected. After admission, the level of CLEC-2 in plasma was detected by enzyme-linked immunosorbent assay; the deaths of 113 patients within 30 days were recorded and divided accordingly. The general clinical data such as gender, age and injury type of the two groups of patients were compared, and multivariate logistic regression was used to analyze the relevant factors that increase the 30-day mortality risk of TBI patients; the receiver operating characteristic curve was plotted to analyze the diagnostic value of CLEC-2 in the early assessment of the 30-day mortality risk of TBI patients. Results: There were 35 deaths within 30 days, with a case fatality rate of 30.97%. Based on this, they were divided into death group (n=35) and survival group (n=78). The GCS score of the death group was lower than that of the survival group, and the proportion of intraventricular hemorrhage, APACHE-II score, age, serum CRP level and CLEC-2 level were higher than those of the survival group, the difference was statistically significant (P<0.05); multivariate logistic regression analysis shown that intraventricular hemorrhage (OR=1.845), older age (OR=1.122), and higher CLEC-2 level (OR=1.022) were independent risk factors leading to an increased risk of 30-day death in TBI patients (P<0.05); The higher GCS score (OR=0.303) is an independent protective factor for 30-day death of TBI patients (P<0.05). ROC curve analysis shows that the area under the curve for early prediction of TBI patients' death by CLEC-2 level is 0.910, which is higher than the GCS score, age and intraventricular hemorrhage; the cut-off point of CLEC-2 for early assessment of the increased risk of death in TBI patients was 314pg/mL, the diagnostic sensitivity was 71.43%, and the specificity was 94.87%. Conclusion: The increase in plasma CLEC-2 concentration is closely related to 30-day death, and it can be used as a new biomarker for clinical evaluation of the risk of death in patients with TBI.
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2021, Vol. 27 
