C242T基因多态性与冠心病的相关性

doi:10.3969/j.issn.1006-6233.2021.12.007

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Abstract Objective: To explore and analyze the correlation between C242T gene polymorphism and coronary heart disease. Methods: A total of 79 patients with coronary heart disease admitted to our hospital from October 2019 to October 2020 were selected as the observation group, and another 96 cases with no coronary heart disease were made the control group. All the enrolled subjects underwent detection of C242T gene polymorphism (gene subtype and allele frequency) with the American OMEGA gene extraction reagent Box. The general data of the two groups of research subjects were compared, and the frequency distribution of different subtypes and alleles in the C242T gene were compared, and the correlation between the C242T gene and coronary heart disease was analyzed by Logistic regression. Results: The incidence of history of hypertension and diabetes in the observation group was higher than that of the control group, and the levels of TG, TC, HDL-C, Hs-CRP, BNP, HCY, LP(a), WBC and other indicators were higher than those of the control group (P<0.05) ; the frequency distribution of TT type, CT type gene and T allele frequency in the C242T gene of the observation group were significantly higher than those of the control group (P<0.05);the level of HDL-C in patients with TT+CT gene carriers was significantly lower than that in patients with CC gene carriers (P<0.05), while there was no significant difference in the levels of other blood lipid indexes among patients with different genotypes (P＞0.05) ;logistic regression analysis was performed on the relevant factors with statistical differences, and the results showed, diabetes (OR=1.422, 95%CI: 1.164～1.737), HDL-C (OR=1.534, 95%CI: 1.011～2.329), HCY (OR=1.241, 95%CI) ：1.159～1.329), carrying T-type gene (OR=1.265, 95%CI: 1.151～1.390) are independent risk factors for coronary heart disease (P<0.05). Conclusion: The TT and CC genotypes in the C242T gene are related to the occurrence of coronary heart disease. TT and CC types are distributed more frequently in patients with coronary heart disease, and T-type gene carriers are at higher risk of coronary heart disease, which can provide clinical diagnosis and prevention and treatment. Guidance basis.

Key words： C242T gene Genotype Gene frequency Coronary heart disease Correlation

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.12.007 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I12/1969

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