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| Changes of Serum Cholinesterase Serum Albumin and Prothrombin Time in Elderly Patients with Liver Cirrhosis and Their Relationship with Child-Pugh Classification |
| DONG Jing, DUAN Yajie |
| Yuncheng Central Hospital, Shanxi Yuncheng 044000, China |
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Abstract Objective: To observe the changes of serum cholinesterase (Che), serum albumin (Alb) and prothrombin time (PT) in elderly patients with liver cirrhosis, and research their relationship with Child-Pugh classification. Methods: A total of 120 elderly patients with liver cirrhosis admitted to the hospital from May 2017 to May 2020 were selected as the study group. The patients were divided into grade A (43 cases), grade B (38 cases), and grade C (39 cases) . Meanwhile, 50 healthy controls were made the control group. Changes of serum Che, Alb, coagulation function-related indicators PT, activated partial thromboplastin time (APTT) and thrombin time (TT) were determined. Pearson correlation analysis was performed to analyze the relationship between the above indicators and Child-Pugh classification. Results: Serum Che and Alb levels in the study group were significantly lower than those in the control group (P<0.05), while coagulation function indicators, PT, APTT and TT were significantly longer than those in the control group (P<0.05). As the Child-Pugh grade of liver cirrhosis increased, the levels of Che and Alb decreased. Pairwise comparison of different Child-Pugh grades of liver cirrhosis showed statistically significant differences (P<0.05). PT, APTT and TT were prolonged as the Child-Pugh grade of liver cirrhosis increased. Pairwise comparison showed that the differences were statistically significant (P<0.05). Spearman correlation analysis found that Che and Alb were negatively correlated with Child-Pugh classification (P<0.05), while PT, APTT and TT were positively correlated with Child-Pugh classification (P<0.05). Conclusion: The improvement of Child-Pugh grade in patients with cirrhosis, serum Che and Alb levels were decreased, while PT, APTT and TT increase.The above indicators were all related to the severity of liver cirrhosis. Therefore, the detection of the above indicators in clinic has a certain positive significance for the assessment of the condition of patients with liver cirrhosis, the formulation of diagnosis and treatment plan and the judgment of prognosis.
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2021, Vol. 27 
