温阳活血汤治疗骨转移癌作用机制探讨

doi:10.3969/j.issn.1006-6233.2021.11.032

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Abstract Objective: To study the mechanism of Wenyang Huoxue Decoction in the treatment of bone metastatic carcinoma by network pharmacology. Methods: TCMSP, TCMID and TCM Database@Taiwan databases and literature search were used to screen the main effective components of drugs. Swiss Target and TCMSP databases were used to search the potential therapeutic targets of Wenyang Huoxue Decoction. DisGeNet and Drugbank databases were used to search the genes of bone metastatic carcinoma. Drug action targets and disease genes were mapped. Cytoscape 3.6.0 software was used to visualize and screen out the core genes. GO and KEGG pathway analysis was performed on potential therapeutic targets. Results: There were 109 main active ingredients in Wenyang Huoxue Decoction, which contained 374 target proteins. There are 773 disease targets of bone metastatic carcinoma, of which 105 are potential targets of Wenyang Huoxue Decoction for the treatment of bone metastatic carcinoma. Through GO and KEGG pathway analysis, it was found that Wenyang Huoxue Decoction exerted anti-cancer, inhibiting bone metastasis and immune system regulation mechanism through HIF-1, TNF, VEGF and other signaling pathways in the treatment of bone metastatic carcinoma. The key genes of Wenyang Huoxue Decoction in treating bone metastatic carcinoma are VEGFA, AKT1, IL6, TP53, ALB, CXCL8, CASP3, TNF, EGFR, EGF and MAPK3 and so on. Conclusion: Through network pharmacology, we found that the mechanism of Wenyang Huoxue Decoction in treating bone metastatic carcinoma involves multiple targets and pathways, which may be related to anti-cancer, inhibition of bone metastasis, regulation of immune system, etc.

Key words： Bone metastatic carcinoma Network pharmacology Wenyang huoxue decoction Mechanism of action

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.11.032 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I11/1922

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