不同浓度氟比洛芬酯超前镇痛对行髋关节置换术老年患者认知功能及IL-6浓度的影响

doi:10.3969/j.issn.1006-6233.2021.11.04

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Abstract Objective: To explore the effect of different concentrations of flurbiprofen axetil on the cognitive function and the concentration of interleukin-6 (IL-6) in elderly patients undergoing hip arthroplasty. Methods: A total of 108 elderly patients undergoing hip arthroplasty in our hospital from March 2018 to March 2021 were selected and simply randomly divided into two groups, with 54 cases in each. The control group received 1.0 mg/kg flurbiprofen axetil as an intravenous bolus, and the study group received 5.0 mg/kg flurbiprofen axetil as an intravenous bolus. The cognitive function [Mini Mental State Scale (MMSE)], pain at 2h, 12h, 24h, 48h after operation (visual simulation Scale (VAS)], IL-6 levels and adverse reactions before operation, immediately after operation, and 24 hours after operation were observed and compared. Results: The two groups were compared in general data such as gender, age, and BMI (P>0.05). The cognitive function MMSE scores of the two groups was compared at different time points. Repeated measures analysis of variance showed that the differences in the time points of the cognitive function MMSE scores between the two groups and the interaction effects between the time points and the groups were statistically significant (P<0.05). The results of the pairwise comparison within the groups afterwards showed that the cognitive function MMSE scores of the two groups of patients 1d after the operation showed a significant downward trend compared with those before the treatment (P<0.05), and the cognitive function MMSE of the two groups of patients 3d after the operation showed a significant upward trend compared with 1 day after operation (P<0.05). The results of the paired comparison between the groups afterwards showed that there was no significant difference in the cognitive function MMSE scores between the two groups on the 1st day before the operation (P>0.05); the cognitive function MMSE scores of the study group were higher than those of the study group 1d after operation and 3d after operation. In the control group, the difference was statistically significant (P<0.05). The VAS pain scores between the two groups were compared at different time points. Repeated measures analysis of variance showed that there were statistically significant differences in the VAS pain scores between the two groups at time points and between groups (P<0.05), and there was no difference in the interaction effects between time points and groups. The difference was tatistically significant (P>0.05). The results of the pairwise comparison within the group showed that the VAS pain scores of the two groups showed a significant upward trend at 12h after surgery compared with 2h after surgery, and the VAS pain scores of the two groups showed a significant downward trend at 24h and 48h after surgery compared to 12h after surgery ( P<0.05). The results of the paired comparison between the groups afterwards showed that the VAS pain scores of the study group were lower than those of the control group at 2h, 12h, 24h, and 48h after the operation, and the difference was statistically significant (P<0.05). The IL-6 levels of the two groups at different time points. Repeated measures analysis of variance showed that the differences in IL-6 levels between the two groups were statistically significant (P<0.05), and the interaction between time points and groups was not statistically significant (P>0.05). The results of a pairwise comparison within the group after the event showed that the IL-6 levels of the two groups immediately after the operation and 24 hours after the operation showed a significant upward trend compared with the pre-operation (P<0.05). The results of the paired comparison between the groups afterwards showed that there was no significant difference in the levels of IL-6 between the two groups before the operation (P>0.05); immediately after the operation and 24 hours after the operation, the IL-6 levels of the study group were lower than those of the control group. The difference was statistically significant (P<0.05). In terms of safety evaluation, 2 cases (3.70%) had nausea in the study group and 1 case (1.85%) had a rash in the control group. There was no significant difference in adverse reactions between the two groups (χ²=3.343, P=0.558>0.05). Conclusion: Preemptive analgesia for elderly patients undergoing hip replacement surgery with 5.0 mg/kg flurbiprofen axetil is beneficial to improving the cognitive function of the patients, which can reduce the surgical pain of the patients, reduce the level of inflammatory factors, and is safe and reliable.

Key words： Hip replacement Flurbiprofen axetil Preemptive analgesia Cognitive function Interleukin-6

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	Articles by authors
	WU Zhiping
	AN Xiaogang
	KONG Yajun

Cite this article:

WU Zhiping,AN Xiaogang,KONG Yajun. Effect of Preemptive Analgesia with Different Concentrations of Flurbiprofen Axetil on Cognitive Function and IL-6 Concentration in Elderly Patients Undergoing Hip Arthroplasty[J]. HeBei Med, 2021, 27(11): 1777-1782.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.11.04 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I11/1777

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