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Efficacy of Enalapril Maleate Folic Acid Tablets in the Treatment of Elderly H-Type Hypertension with Acute Cerebral Infarction and Its Influence on Levels of SAA LP(a) NT-ProBNP and Hcy |
ZENG Yuhong, XIAO Yin, CHEN Lin |
The Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Hainan Haikou 570208, China |
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Abstract Objective: To observe the efficacy of enalapril maleate folic acid tablets in the treatment of elderly H-type hypertension with acute cerebral infarction (ACI) and the influence on serum amyloid A (SAA), lysophosphatidic acid [LP(a)], N-terminal pro-B-type natriuretic peptide (NT-proBNP) and homocysteine (Hcy). Methods: Totally 153 elderly patients with H-type hypertension complicated with ACI treated in our hospital between October 2018 and October 2020 were selected as observation subjects, and they were classified into observation group (n=79) and control group (n=74) according to the random number table method. Patients in the control group were given conventional therapy, and patients in the observation group were additionally treated with enalapril maleate folic acid tablets based on the control group. The clinical efficacy of patients was compared, and the blood pressure, serum-related indexes [SAA, LP(a), NT-proBNP, Hcy], cognitive function [Mini-Mental State Examination (MMSE)], neurological function [National Institutes of Health Stroke Scale (NIHSS)] and self-care ability of daily living [Barthel Index (BI)] were observed in the two groups before treatment and 3 months after treatment. Results: The total clinical effective rate was significantly increased in observation group compared with that in control group (97.47% vs 89.19%), and the basic recovery rate was significantly higher than that in control group (P<0.05). 3 months after treatment, the blood pressure level of the two groups was obviously reduced compared to before treatment, and the reduction was more significant in observation group, and was closer to the normal level (P<0.05). The levels of SAA, LP(a), NT-proBNP and Hcy and score of NIHSS in both groups were lower than those before treatment, and the decreases in observation group were more obvious (P<0.05). The scores of AMSE and BI were risen in two groups of patientsthan those before treatment, and observation group had marked increases (P<0.05). Conclusion: Enalapril maleate folic acid tablets for elderly H-type hypertension with ACI has a significant effect in improving the blood pressure level, reducing levels of SAA, LP(a), NT-proBNP and Hcy, improving neurological function, and enhancing cognitive function and self-care ability of daily living.
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