双嘧达莫辅助治疗川崎病患儿的疗效及对抗血小板聚集相关因子免疫功能 CRP及PCT水平的影响

doi:10.3969/j.issn.1006-6233.2021.10.031

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1264 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To observe the efficacy of dipyridamole in treating KD, and its effects on platelet related parameters, immune function, serum CRP and PCT. Methods: 68 children with KD admitted to our hospital from February 2019 to February 2021 were prospectively selected as the study subjects. All the children were divided into 2 groups with 34 cases in each group by simple numerical random table method. The control group underwent conventional treatment, and the observation group underwent dipyridamole. Clinical indexes, platelet-related parameters (PLT, WBC, ESR), serum CRP, PCT levels, and immune function indexes (CD3⁺, CD4⁺, CD8⁺, IgA, IgG, IgM) were compared. Results: The subside time of fever, mucosal congestion, limb swelling, lymph node enlargement symptoms and the length of hospital stay in the observation group were significantly lower than those in the control group (P<0.05). The incidence of CAL in the observation group was 14.71%, which was significantly lower than 38.24% in the control group (P<0.05). After treatment, blood PLT, WBC, ESR, CRP and PCT in 2 groups were significantly lower than those before treatment (P<0.05). After treatment, blood PLT, WBC, ESR, CRP and PCT in observation group were significantly lower than those in control group (P<0.05). The differences of blood PLT, WBC, ESR, CRP and PCT in observation group were higher than those in control group before and after treatment (P<0.05). After treatment, CD4⁺ was significantly lower than before treatment (P<0.05), while CD8⁺, IgA and IgG were significantly higher than before treatment (P<0.05). After treatment, CD4⁺ in observation group was significantly lower than that in control group (P<0.05), and CD8⁺, IgA and IgG in observation group were significantly higher than those in control group (P<0.05). The differences of CD3⁺, CD4⁺, CD8⁺, IgA, IgG, IgM in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion: Dipyridamole can improve anti-platelet aggregation ability, enhance immune function, and reduce serum CRP and PCT levels in children with KD, finally it achievs the effect of promoting rehabilitation efficiency and reduces the incidence of CAL.

Key words： KD Dipyridamole Aspirin Gamma globulin Anti-platelet aggregation Immune function

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Fengjuan
	XING Yaming

Cite this article:

WANG Fengjuan,XING Yaming. Effects of Dipyridamole Adjuvant Therapy on Platelet-Related Parameters Immune Function, CRP and PCT Levels in Children with KD[J]. HeBei Med, 2021, 27(10): 1724-1728.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.10.031 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I10/1724

[1] Piram M,Burns J C.Kawasaki disease for the paediatric dermatologist:skin manifestations and new insights into the pathophysiology[J].Clinical & Experimental Dermatology,2021,46(3):503~509.
[2] Duan J,Jiang H,Lu M.Risk factors for coronary artery lesions in children with Kawasaki disease[J].Archivos Argentinos De Pediatria,2020,118(5):327~331.
[3] Geng Z,Liu J,Hu J,et al.Crucial transcripts predict response to initial immunoglobulin treatment in acute Kawasaki disease[J].Scientific Reports,2020,10(1):17860.
[4] 林爱弟,蓝陈福,李司鹏,等.不同治疗方案对川崎病患儿临床疗效及CRP,PCT的影响[J].中国妇幼健康研究,2019,30(8):995~998.
[5] Ayusawa M,Sonobe T,Uemura S,et al.Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition).[J].Pediatrics International,2010,47(2):232~234.
[6] Mccrindle B W,Rowley A H,Newburger J W,et al.Diagnosis,treatment,and long-term management of kawasaki disease:a scientific statement for health professionals from the American heart association[J].Circulation,2017,135(17):e927.
[7] Schexnayder A G,Tang X,Collins R T,et al.Pericardial effusion in children admitted with kawasaki disease:a multicenter retrospective cohort study from the pediatric health information system[J].Clinical Pediatrics,2021,60(1):9~15.
[8] Lorenzoni R P,Elkins N,Quezada M,et al.Coronary artery involvement in children with kawaskidisease using the pedia tric heart network Z score system[J].Journal of the American College of Cardiology,2020,75(11):573.
[9] 刘懿,陈伟芝,邵亚望.血清Omentin-1和Lp-PLA2水平检测在川崎病中的应用价值[J].河北医科大学学报,2021,42(3):339~343.
[10] 章建龙,姜文涛.阿司匹林与氯吡格雷对冠心病的治疗效果比较[J].中国基层医药,2019,26(16):1925~1928.
[11] Yu H J,Chuang M N,Chu C L,et al.Intravenous immunoglobulin treatment in kawasaki disease decreases the incidence of myopia[J].Journal of Clinical Medicine,2021,10(7):1381.
[12] 王茹,戚昌丽.双嘧达莫联合丙种球蛋白及阿司匹林治疗川崎病疗效及对患儿免疫功能和凝血功能的影响[J].河北医学,2021,27(2):317~321.
[13] 何琳琳,李琴,刘定远,等.双嘧达莫辅助治疗川崎病患儿的疗效及对T淋巴细胞亚群,凝血功能影响[J].现代生物医学进展,2020,20(10):1929~1932,1904.