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| Curative Effect of Penciclovir Combined with Aciclovir Ointment on Herpes Zoster and the Changes of Pain Serum IL-2 and IL-6 Levels |
| YANG Yuanfeng, SU Shengxian, XIE Xiaoli |
| Zhongshan People's Hospital, Guangdong Zhongshan 528403, China |
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Abstract Objective: To explore the curative effect of penciclovir combined with aciclovir ointment on herpes zoster and the changes of pain, serum interleukin-2 (IL-2) and interleukin-6 (IL-6) levels. Methods: A total of 142 patients with herpes zoster admitted to the hospital between September 2016 and October 2020 were enrolled as the research objects. They were divided into observation group and control group by simple random grouping method, 71 cases in each group. The control group was treated with routine ointment, while observation group was additionally treated with penciclovir. The curative effect and improvement time of clinical symptoms [scabbing time of herpes zoster, stopping development time of blisters, disappearance time of pain], scores of Visual Analogue Scale (VAS) before and after treatment, changes in levels of serum inflammatory factors [IL-2, IL-6, interleukin-10 (IL-10)] and T cell subsets [T lymphocyte (CD3+), Helper T cells (CD4+), Cytotoxic T cells (CD8+), CD4+/CD8+] before and after treatment were compared between the two groups. The incidence of adverse reactions during treatment was recorded. Results: At 7d after treatment, the response rate of treatment in observation group was higher than that in control group (P<0.05). The improvement time of clinical symptoms in observation group was shorter than that in control group (P<0.05). After treatment, VAS scores in both groups were decreased, which were lower in observation group than control group (P<0.05). After treatment, levels of IL-2 and IL-10, CD3+, CD4+ and CD4+/CD8+ in both groups were increased, which were higher in observation group than control group (P<0.05), while IL-6 level was decreased, which was lower in observation group than control group (P<0.05). There was no significant difference in the incidence of adverse reactions during treatment between the two groups (P>0.05). Conclusion: Curative effect of penciclovir combined with aciclovir ointment is significant on herpes zoster, it can relieve neuropathic pain, shorten disappearance time of symptoms, regulate inflammatory factors, and improve immune function, with high safety.
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2021, Vol. 27 
