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| An Observation of Anesthesia Effect of Dexmedetomidine Combined with Endotracheal Laryngeal Mask Intubation in Cervical Surgery |
| ZHANG Xuewei, SUN Yanbin, WANG Wenxi, et al |
| Chengde Central Hospital, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the effects of anesthesia and stress response of dexmedetomidine combined with endotracheal intubation laryngeal mask (ILMA) in patients undergoing cervical surgery. Methods: 120 patients with cervical spine surgery of ASA Ⅰ/Ⅱ from February 2017 to February 2019 in our hospital for treatment were divided into observation group and control group by simple random number table method, 60 cases in each group. The observation group was treated with dexmedetomidine combined with ILMA, while the control group was treated with normal saline combined with ILMA. Changes of hemodynamic indexes and inflammatory stress indexes [serum cortisol (COR), epinephrine (E), norepinephrine (NE), interleukin-6 (IL-6), tumor necrosis factor (TNF-α) and C-reactive protein (CRP)] of two groups of patients before anesthesia (T0), immediate intubation (T1), before extubation (T2) and 5 min after extubation (T3) were compared. Results: Compared with the control group, HR and MAP in the observation group at T1, T2 and T3 were significantly lower than those in the control group, the difference was statistically significant (P<0.05), while there was no statistical significance between the two groups at T0 (P>0.05). Compared with T0, HR and MAP in the control group were significantly increased at T1, T2 and T3, with statistical significance (P<0.05). Compared with the control group, the expression levels of stress in observation group at T1, T2 and T3 were significantly decreased, with statistical significance (P<0.05). Compared with T0, the expression levels of stress indicators in 2 groups were significantly up-regulated at T1, T2 and T3, with statistical significance (P<0.05), while there was no statistical significance between the two groups at T0 (P>0.05). Conclusion: The application of dexmedetomidine combined with endotracheal intubation laryngeal mask in cervical spine surgery can significantly reduce the inflammatory stress response and effectively maintain hemodynamic stability.
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2021, Vol. 27 
