腹透引流液中IL-6及NGAL检测对腹透相关性腹膜炎的诊断价值

doi:10.3969/j.issn.1006-6233.2021.10.019

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1414 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the diagnostic value of peritoneal dialysis (PD) drainage fluid interleukin-6 (IL-6) and neutrophil gelatinase-associated lipocalin (NGAL) in peritoneal dialysis-associated peritonitis (PDAP). Methods: A total of 120 patients hospitalized in the nephrology department and undergoing PD in the hospital between January 2019 and September 2020 were selected as study objects. According to the presence or absence of PDAP, the patients were divided into PDAP group and non-PDAP group. The levels of drainage fluid IL-6 and NGAL in the two groups were compared, and their diagnostic valuein PDAP was analyzed. Results: Follow-up revealed that 55 of the 120 patients developed PDAP. The drainage fluid IL-6, NGAL and WBC, and dialysis age of the PDAP group were significantly higher or longer than those of the non-PDAP group (P<0.05). Drainage fluid IL-6, NGAL and WBC, and dialysis age were independent risk factors for PDAP. Both IL-6 and NGAL single detection were of high value in the diagnosis of PDAP. Conclusion: IL-6 and NGAL in drainage fluid are independent risk factors for PDAP, which provides an effective basis for the diagnosis of PDAP.

Key words： Peritoneal dialysis-associated peritonitis Peritoneal dialysis drainage fluid IL-6 NGAL Diagnostic value

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.10.019 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I10/1675

[1] 佟琰.液体(腹透流出液)活检在腹膜透析相关并发症中的应用进展[J].国际泌尿系统杂志,2019,39(4):730~734.
[2] Cetin N,Sav NM,Ciftci E,et al.Foreign body reaction to di-alysis chatheter and peritoneal fluid cosinophilia in a child oncontinuous ambulatory peritoncal dialysis[J].Iran KidneyDis,2017,11(4):319~321.
[3] Catar R,Witowski J,'Zhu N,et al.IL-6 trans-sigaling links in-flammation with angiogenesis in the peritoneal memlbrane[J].Am Soc Nephrol,2017,28(4):1188~1199.
[4] Cullaro G,Kim G,Perira M R,et al.Ascites necutrophil gelati-nase - associated lipocalin idlentifies spontancous bacterial peritoni-tis and predicts mortality in hoespitalized patients with cinrhosis[J].Dig Dis Sci,2017,62(12):3487~3494.
[5] Takeuchi T,Ohno H,Satoh-Takay ama N,et al.Understandling the im-mune signalure fingerprint of peritoneal dialysis-related peritonitis[J].Kidney Int,2017,92(1):16~18.
[6] Aufricht C,Beeken R,Eberl M,at al.Biomarker research to im-prove clinmical outcomes of peritomeal dialysis; consensus of the eu-ropean training and research in peritoneal dialysis (ExTRiPD)neatwork[J].Kidney Int,2017,92(4):824~835.
[7] Zhang Z,Jiang N,Ni Z.Strategies for preventing peritoneal fi-brosis in peritoneal dialysis patients:new insights based onperitoneal inflammation and angiogenesis[J].Front Med,2017,11(3):349~358.
[8] Xu T,Xie J,Wang w.et al.Resting energy expenditure:avaluable predictor for KT/Vurea in peritoneal dialysis pa-tients[J].Clin Nephrol,2017,88(9):124~131.
[9] 李爽,郭小兵,刘娜,等.腹膜透析相关性腹膜炎患者感染学特点及预后转归分析[J].现代预防医学,2020,47(2):367~370,380.
[10] 李娟,郭志勇,赖学莉,等.腹膜透析患者腹透液中HIF-1α与TGF-β₁,IL-6,CRP及腹膜转运功能的相关性研究[J].中国中西医结合肾病杂志,2013,4(4):313.
[11] 严月华,杨春慧,纪天蓉,等.探讨腹膜透析相关性腹膜炎不同转归患者的临床特点[J].中国血液净化,2020,19(2):77~80.