阿尔茨海默病患者血清miR-137 ABCA7水平变化及临床意义

doi:10.3969/j.issn.1006-6233.2021.10.014

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Abstract Objective: To investigate the changes and clinical significance of serum microRNA (miRNA)-137 and adenosine triphosphate binding cassette transporter 7 (ABCA7) levels in patients with Alzheimer's disease (AD). Methods: A total of 138 AD patients admitted to our hospital from January 2018 to December 2019 were selected as the AD group. According to the clinical dementia rating (CDR) scale, they were divided into mild group (n=48) and moderate group (n=59), severe group (n=31), and 64 healthy people during physical examination during the same period were selected as the control group. Spearman correlation analysis was conducted to analyze the correlation between AD group's serum miR-137, ABCA7 levels and serum Aβ42, Aβ40, Aβ42/Aβ40, blood lipid levels and MMSE score. ROC curve was plotted to analyze serum miR-137 and ABCA7 levels in the diagnosis of AD. Results: The serum miR-137, Aβ42, high-density lipoprotein cholesterol (HDL-C) levels, Aβ42/Aβ40 and MMSE scores in the AD group were significantly lower than those in the control group, and ABCA7, Aβ40, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher than those of the control group (P<0.05). Spearman correlation analysis showed that serum miR-137 levels in AD group were positively correlated with Aβ42, Aβ42/Aβ40, HDL-C and MMSE scores, and negatively correlated with Aβ40, TC, LDL-C levels, and CDR scale (P<0.05); Serum ABCA7 levels were negatively correlated with Aβ42, Aβ42/Aβ40, HDL-C and MMSE scores, and positively correlated with Aβ40, TC, LDL-C levels, and CDR scale (P<0.05). The ROC curve showed that the area under the curve (AUC=0.925) of miR-137+ABCA7 for the diagnosis of AD was significantly greater than that of miR-137 (AUC=0.837), ABCA7 (AUC=0.823) in diagnosed alone (P<0.05), and the sensitivity and specificity were 85.51% and 84.37%. Conclusion: The level of serum miR-137 in AD patients is significantly reduced, and the level of ABCA7 is significantly increased. It is closely related to Aβ deposition, abnormal cholesterol metabolism, and disease condition in AD patients. It may be a marker for AD diagnosis and disease severity assessment. The combined detection of the two is more valuable.

Key words： Alzheimer's disease MicroRNA-137 Adenosine triphosphate binding cassette transporter 7 β-amyloid protein Cholesterol

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.10.014 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I10/1652

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