儿童不同亚型呼吸道合胞病毒感染的临床流行特征及气候因素分析

doi:10.3969/j.issn.1006-6233.2021.10.010

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Abstract Objective: To investigate the epidemiological characteristics, clinical characteristics and climatic factors of different subtypes of respiratory syncytial virus (RSV) in children. Methods: A total of 309 children with acute lower respiratory tract infection infected by RSV were collected from our hospital from January 2018 to December 2020. The epidemiological characteristics, clinical characteristics and climatic characteristics of different subtypes of RSV infection were analyzed; Spearman correlation was used to analyze the correlation between different RSV subtypes and climate characteristics. Results: Among the 309 cases of RSV, 186 cases (60.19%) of RSV-A and 123 cases (39.81%) of RSV-B were found, with RSV-A type as the dominant type; RSV-A and RSV-B groups showed statistically significant differences in different years and seasons (all P<0.05). In 2018 and 2019, RSV-B was the dominant infection group, and in 2020, RSV-A was the dominant infection group. Children infected with RSV-A and RSV-B were mainly infected under 3 years old, in winter and spring and had mild symptoms, there was no significant difference between RSV-A group and RSV-B group in terms of age and severity of disease (all P>0.05). There was no significant difference between RSV-A and RSV-B in fever, cough, wheezing, mixed infection and other clinical symptoms, course of disease and length of hospital stay (all P>0.05); Spearman correlation analysis showed that RSV-A infection was positively correlated with PM2.5, PM10, SO₂, NO₂ and CO (r=0.658, P<0.001; r = 0.612, P = 0.002; r = 0.501, P = 0.008; r = 0.728, P = 0.001; r =0.642, P<0.001), was negatively correlated with mean temperature, monthly total rainfall, monthly mean wind speed and O₃ (r=-0.592, P=0.001; r = 0.502, P = 0.005; r = 0.618, P = 0.002; r =-0.654, P<0.001); RSV-B infection was positively correlated with CO (r=0.559, P<0.001), and negatively correlated with monthly mean temperature, monthly total rainfall and O₃ (r=-0.581, P=0.001; r = 0.368, P = 0.025; r =-0.598, P<0.001). Conclusion: RSV-A type is the dominant type of RSV infection in children, and RSV-A type is the dominant type of RSV infection in children under 3 years old, winter and spring, and mild symptoms. Different subtypes of RSV infection are related to climate and environmental factors.

Key words： Respiratory syncytial virus Lower respiratory tract infection Clinical features Climate factors

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	Articles by authors
	WU Shouye
	LIN Daojiong
	WANG Yazhou

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WU Shouye,LIN Daojiong,WANG Yazhou. Clinical Epidemiological Characteristics and Climatic Factors of Different Subtypes of Respiratory Syncytial Virus Infection in Children[J]. HeBei Med, 2021, 27(10): 1632-1636.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.10.010 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I10/1632

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