自拟补肾调经方加味治疗多囊卵巢综合征效果及血清AMH LH和FSH水平的影响

doi:10.3969/j.issn.1006-6233.2021.09.037

Abstract
Figure/Table
References
Related Citation (9)

Download: PDF (1225 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To analyze the treatment effect of self-made Bushen Tiaojing decoction on polycystic ovary syndrome (PCOS). Methods: A total of 140 patients with PCOS (kidney deficiency and phlegm stasis syndrome) who came to our hospital between March 2018 and February 2020 were selected as the research subjects, and they were randomly divided into observation group and control group according to the random number table method, with 70 cases in each group. Control group was given ethinylestradiol and cyproterone acetate tablets and conventional western medicine treatment, and observation group was given Jiawei self-made Bushen Tiaojing decoction on the basis of control group. The TCM syndromes scores, uterine-related indexes [endometrial thickness, ovarian volume, cervical mucus score (Insler cervical scoring method)], serum related factors [serum anti-Mullerian hormone (AMH), luteinizing hormone (LH), follicle stimulating hormone (FSH)] and occurrence of adverse reactions were compared between the two groups of patients before treatment and at 6 months of treatment. The ovulation rate and natural pregnancy rate were recorded in the two groups of patients during 1-year follow-up. Results: The scores of symptoms of irregular menstruation, soreness and weakness of waist and knees, fatigue, abnormal leukorrhea and dysmenorrhea in the two groups of patients after 6 months of treatment were significantly lower than those before treatment, and the scores of observation group were significantly lower than those of control group (all P<0.05). And the differences of symptoms scores before and after treatment in observation group were significantly higher than those in control group (all P<0.05). The endometrial thickness and cervical mucus score of the two groups of patients at 6 months of treatment were significantly increased compared with those before treatment while the ovarian volume was significantly decreased compared with that before treatment, and there were statistically significant differences between observation group and control group (all P<0.05), and the differences of indicators changes before and after treatment were significantly different between the two groups (all P<0.05). At 6 months of treatment, the levels of serum AMH, LH and FSH of the two groups were significantly reduced compared with those before treatment, and the levels of AMH and LH in observation group were significantly lower than those in control group (all P<0.05). There was no significant difference in FSH level between the two groups (P>0.05), and there were statistical significance in the differences of indicators before and after treatment between the two groups (all P<0.05). There were no significant differences in the occurrence of adverse reactions such as dizziness, nausea and mild abdominal pain between the two groups of patients during treatment (P>0.05). At 1-year follow-up, the ovulation rate and natural pregnancy rate of observation group were significantly higher than those of control group (all P<0.05). Conclusion: Jiawei Bushen Tiaojing decoction in the treatment of PCOS (kidney deficiency and phlegm stasis syndrome) can effectively improve the symptoms of irregular menstruation and fatigue as well as ovarian function, and it is conducive to smooth ovulation and promotion of natural pregnancy. It has a definite efficacy and good safety.

Key words： Bushen tiaojing decoction Polycystic ovary syndrome TCM syndromes score Ovulation rate Natural pregnancy rate

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Lina
	XIN Huan
	YANG Min

Cite this article:

ZHOU Lina,XIN Huan,YANG Min. Effect of Jiawei Self-made Bushen Tiaojing Decoction on Polycystic Ovary Syndrome and Its Influence on Levels of Serum AMH LH and FSH[J]. HeBei Med, 2021, 27(9): 1572-1577.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.09.037 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I9/1572

[1] 袁莹莹,赵君利.多囊卵巢综合征流行病学特点[J].中国实用妇科与产科杂志,2019,35(3):9~12.
[2] Chantrapanichkul P,Indhavivadhana S,Wongwananuruk T,et al.Prevalence of type 2 diabetes mellitus compared between lean and overweight/obese patients with polycystic ovarian syndrome:a 5-year follow-up study[J].Archives of Gynecology and Obstetrics,2020,301(1):224~228.
[3] 王峥,潘晓蕾,刘昭阳,等.多囊卵巢综合征中医证型与性激素、卵巢体积相关性研究[J].中国中医基础医学杂志,2019,25(4):490~492,534.
[4] 宋翠淼,李志丽,杨江霞,等.补肾调经方对控制性超促排卵小鼠卵巢组织形态学、白血病抑制因子表达的影响[J].中成药,2018,40(8):1815~1818.
[5] Fauser B,Tarlatzis B C,Rebar R W,et al.Consensus on women's health aspects of polycystic ovary syndrome (PCOS):the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group[J].Fertility & Sterility,2012,97(1):28~38.
[6] 郑筱萸.中药新药临床研究指导原则:试行[J].中国医药科技出版社,2002,5(6):114~117.
[7] 韩国征,孙良佐.补肾调冲方治疗肾阳亏虚型不孕症疗效观察[J].中华中医药学刊,2019,37(12):216~219.
[8] 乔世聪,夏敏,侯丽辉,等.多囊卵巢综合征患者中医证候分布特点及各证型患者临床特征研究[J].实用医学杂志,2018,34(4):653~656,664.
[9] 彭孟凡,刘保松,苗明三.补肾法治疗多囊卵巢综合征的理论探讨[J].中国实验方剂学杂志,2019,25(6):212~217.
[10] 张琼.多囊卵巢综合征的中医治疗[J].中国现代药物应用,2020,14(18):251~253.
[11] Bansal P,Sardana K,Arora P,et al.A prospective study of anti-ullerian hormone and other ovarian and adrenal hormones in adult female acne[J].Dermatologic Therapy,2020,12(5):321~326.
[12] 芦艳丽,李娟,韩璐.补肾调经膏方治疗肾虚型卵巢早衰的临床研究[J].世界中西医结合杂志,2019,14(3):388~391,395.
[13] 黄长盛,贺守第,管雁丞,等.菟丝子黄酮和槲皮素对雷公藤多苷致卵巢早衰大鼠卵巢功能的影响[J].中国临床药理学杂志,2020,36(6):667~670.
[14] 李虎虓,宋忠臣.补骨脂素的植物雌激素样作用研究进展[J].上海交通大学学报(医学版),2019,39(2):105~108.