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| Curative Effect of Minimally Invasive Nasal Endoscopic Surgery on Sinusitis and Its Influences on Serum ECP HMGB1 IL-1β and IL-21 Levels |
| WANG Mingxiang, ZHANG Shaofang, CHEN Wei, et al |
| Chenzhou First People's Hospital, Hunan Chenzhou 423000, China |
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Abstract Objective: To explore the curative effect of minimally invasive nasal endoscopic surgery on sinusitis and its influences on levels of serum eosinophile cationic protein (ECP), high mobility group protein B1 (HMGB1), interleukin-1β (IL-1β) and interleukin-21 (IL-21). Methods: A total of 163 sinusitis patients treated in the hospital from January 2019 to October 2020 were enrolled and divided into observation group (81 cases) and control group (82 cases) by random number table method. The control group was treated with microwave thermo-coagulation, while observation group was treated with minimally invasive nasal endoscopic surgery. Both groups were followed up for 3 months. The clinical curative effect after 3 months of treatment between the two groups was compared. Before and after treatment, subjective symptoms of sinusitis were evaluated by visual analogue scale (VAS). The morphology of nasal mucosa was evaluated by Lund-Kennedy endoscope scoring method. And their quality of life was assessed by sinonasal outcometest-20 (SNOT-20). The levels of ECP, HMGB1, IL-1β and IL-21 before and after treatment between the two groups were compared. Results: After treatment, the total response rate was higher in observation group than control group (92.59% vs 81.71%) (P<0.05). After treatment, scores of VAS (runny nose, nasal congestion, cheek pain, headache, hyposmia) in observation group were (2.03±0.52) points, (2.15±0.58) points, (1.24±0.37) points, (0.96±0.32) points and (1.25±0.31) points, lower than those in control group [(3.45±0.84) points, (3.21±0.74) points, (2.08±0.56) points, (1.36±0.41) points, (2.62±0.48) points] (P<0.05). After treatment, scores of Lund-Kennedy and SNOT-20 in observation group were (1.51±0.42) points and (2.08±0.62) points, lower than those in control group [(2.52±0.67) points, (3.61±0.86) points] (P<0.05). After treatment, levels of ECP, HMGB1, IL-1β and IL-21 in observation group were (4.23±1.08) ng/L, (64.25±6.13) μg/L, (30.25±4.36) pg/mL and (72.16±12.34) pg/mL, lower than those in control group [(5.46±1.31) ng/L, (72.18±7.29) μg/L, (38.47±5.19) pg/mL, (86.25±14.17) pg/mL] (P<0.05). Conclusion: Curative effect of minimally invasive nasal endoscopic surgery is good on sinusitis, which can effectively improve clinical symptoms of patients, reduce allergic reactions and inflammation level, and improve their quality of life.
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2021, Vol. 27 
