标准大骨瓣减压后关闭硬脑膜对重型颅脑损伤患者血清S100β NSE水平及术后并发症发生率的影响

doi:10.3969/j.issn.1006-6233.2021.09.030

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Abstract Objective: To investigate the effect of closing the dura mater after standard large bone flap decompression on serum S100β, neuron specific enolase (NSE) levels and the incidence of postoperative complications in patients with severe head injury (SHI). Methods: A total of 80 SHI patients in our hospital from February 2019 to June 2020 were selected and divided into study group (n=41) and control group (n=39) according to different treatment plans. In study group, the dura mater was closed after standard large bone flap decompression, while in control group, it was not closed. The related indexes, complications, serum S100β and NSE levels before operation, 3 d and 7 d after operation were compared, as well as the neurological function score (NIHSS) and glasgow coma scaley score (GCS) before operation, 2 weeks and 1 month after operation, the cognitive function score (MMSE), ability of daily living score (BI), and quality of life score (GQOLI-74) before operation, 3 months and 6 months after operation between the two groups. The prognosis of 6 months after operation was calculated. Results: The length of stay in ICU of study group was shorter than that of control group (P<0.05). The serum S100β and NSE levels of study group were lower than those of control group at 3 and 7 days after operation (P<0.05). The NIHSS score of study group was lower than that of control group at 2 weeks and 1 month after operation, and the GCS score of study group was higher than that of control group (P<0.05). The scores of MMSE, BI and GQOLI-74 in study group were higher than those in control group at 3 months and 6 months after operation (P<0.05). The postoperative complication rate of study group was 12.20% lower than that of 30.77% in control group (P<0.05). The prognosis of study group was better than that of control group at 6 months (P<0.05). Conclusion: Closing the dura mater after decompressing the standard large bone flap in SHI patients can reduce serum S100β and NSE levels, reduce complications, improve cognitive function and daily activities, improve quality of life, and have important brain protection effects.

Key words： Standard large bone flap decompression Closure of the dura Severe head injury Complications S100β Neuron specific enolase

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	ZHANG Huajun
	DIAO Zhengwen
	DU Chunfu
	et al

Cite this article:

ZHANG Huajun,DIAO Zhengwen,DU Chunfu, et al. Effect of Closing the Dura Mater after Standard Large Bone Flap Decompression on Serum S100β and NSE Levels and the Incidence of Postoperative Complications in Patients with Severe Head Injury[J]. HeBei Med, 2021, 27(9): 1540-1544.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.09.030 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I9/1540

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