腺样体肥大伴变应性鼻炎患儿致敏原谱及腺样体组织中IL-25 IL-32 EOS表达分析及诊断价值

doi:10.3969/j.issn.1006-6233.2021.09.025

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Abstract Objective: To analyze the allergen spectrum of children with adenoid hypertrophy and allergic rhinitis and the expression of IL-25, IL-3 and EOS in adenoid tissues and their diagnostic value. Methods: 96 children with allergic rhinitis were selected as the clinical data of the study for retrospective analysis. The study period was from May 2017 to May 2020. Patients with adenoid hypertrophy and allergic rhinitis were selected according to the 1:1 individual matching principle. 48 Cases make up group A and 48 cases of patients with simple allergic rhinitis make up group B. In addition, 48 healthy subjects were selected as the control group, and the allergen spectrum of children with allergic rhinitis was observed, the IL-25, IL-32, and EOS of the three groups of subjects were evaluated, and the adenoid hypertrophy and degeneration were analyzed. The independent influencing factors of patients with atopic rhinitis, the correlation between IL25, IL32 and EOS, and the AUC value of IL25, IL32, EOS and the combination of the three. Results: 96 children with allergic rhinitis were tested for serum allergen total IgE, 94 cases (97.92%) were positive; 42 cases (44.68%) were allergic to only one allergen, and were allergic to more than two kinds of allergens. There were 52 cases (55.32%) of primary allergies. Among the inhaled allergens, the positive rate of house dust mites was the highest, and the positive rate of dog dander was the lowest; among the inhaled allergens, the positive rate of chicken protein was the highest, and the positive rate of fish, crabs and shrimps was the lowest. The levels of IL-25, IL-32 and EOS in group A and B were higher than those in the control group (all P<0.05); the levels of IL-25, IL-32 and EOS in group A were higher than those in group B (all P<0.05). The binary logistic regression analysis showed that IL-25, IL-32 and EOS were all independent influencing factors in patients with adenoid hypertrophy and allergic rhinitis (P<0.05). Pearson correlation analysis showed that IL25, IL32 and EOS were positively correlated (r=0.742/0.871, P<0.05). ROC curve analysis showed that the AUC values of IL-25, IL-32, EOS, and the three items combined to predict adenoid hypertrophy with allergic rhinitis were (0.855, 0.977, 0.996, 0.994, P<0.05); the sensitivity was respectively Are (72.90%, 95.80%, 93.80%, 100.00%), specificity is (91.70%, 93.70%, 100.00%, 91.70%). Conclusion: IL-25, IL-32 and EOS are abnormally expressed in children with adenoid hypertrophy and allergic rhinitis, and they have a certain guiding role in clinical diagnosis.

Key words： Adenoid hypertrophy Allergic rhinitis Allergen spectrum Adenoid tissue IL-25 IL-32 EOS

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.09.025 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I9/1517

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