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| CT Perfusion Imaging Evaluates the Curative Effect of NP Chemotherapy Combined with Brucea Javanica Oil Emulsion in the Treatment of Non-Small Cell Lung Cancer |
| LI Chuangui, LIU Xiaocheng, ZHANG Xinhui, et al |
| The First Affiliated Hospital of Hebei North University, Hebei Zhangjiakou 075000, China |
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Abstract Objective: To evaluate the clinical application value of NP chemotherapy combined with Brucea javanica oil emulsion in the treatment of non-small cell lung cancer using CT perfusion imaging technology. Methods: The imaging data of 40 patients with non-small cell lung cancer admitted to the First Affiliated Hospital of Hebei North University from January 2017 to December 2018 were retrospectively analyzed. According to the treatment plan, they were divided into observation group (n=20) and control group ( n=20). The control group was treated with conventional NP chemotherapy during 3 consecutive treatment cycles, 21 days in a cycle. The observation group was given intravenous drip of Brucea javanica oil emulsion 30ml and 0.9% sodium chloride injection 250ml in the same perion, 2 times/day, 28 days in a cycle, for 3 consecutive cycles of treatment. TOSHIBA Aquilion One 320-row CT scanner was used for conventional lung CT scan and Target lesion perfusion scan before and after 3 cycles of treatment, and data were recorded, including the changes in lesion size before and after treatment, perfusion parameter values: blood flow (BF), blood volume (BV), mean transit time (MTT), capillary permeability (PS) between groups. Results: After 3 cycles of treatment, the remission rate of the observation group was 60% (12/20), and the remission rate of the control group was 45% (9/20). The remission rate of the observation group was higher than that of the control group (60.0%∶45.0%). The difference was not statistically significant (χ2=0.902, P=0.342); after treatment, the BV and BF levels of the two groups decreased, and the observation group was lower than the control group (P<0.05), the MTT levels of the two groups increased (P<0.05); PS levels in the two groups decreased after treatment, and the observation group was lower than the control group, but the difference was not statistically significant (P>0.05). Conclusion: Brucea javanica oil emulsion is safe and effective in adjuvant treatment of lung cancer. It can inhibit the proliferation of tumor cells, improve the microcirculation of tumor tissues, and improve the immune function of the body. CT perfusion imaging can sensitively reflect the hemodynamic changes of lung cancer lesions, which is the curative effect of lung cancer. The evaluation provides objective functional imaging basis.
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[1] Siegel RL,Miller KD,Jemal A.Cancer statistics,2017[J].CA Cancer Clin,2017,67(1):7~30.
[2] 闵旭红,宋彪.肺癌患者放疗前后CT灌注成像相关研究[J].中华放射肿瘤学杂志,2016,25(7):694~698.
[3] 曾勇,王赤华,徐立军,等.鸦胆子油联合吉西他滨和顺铂治疗晚期非小细胞肺癌的临床观察[J].中国药房,2017,28(14):1945~1948.
[4] Ichikawa T,Machida N,Sasaki H,et al.Early prediction of the outcome using tumor markers and mRECIST in unresectable hepatocellular carcinoma patients who underwent transarterial chemoembolization[J].Oncology,2016,91(6):317~330.
[5] 谭宝利,张进儒.鸦胆子油注射液对Ⅲ期胃癌的疗效及对机体免疫功能的影响[J].世界中医药,2017,12(9):2093~2095,2100.
[6] 杜恩辅,徐霖,周选民,等.鸦胆子油乳介入化疗联合养正消积胶囊治疗原发性肝癌的效果及对患者免疫功能的影响[J].实用癌症杂志,2018,33(2):240~243,250.
[7] 黎鹏,肖志伟,林丽珠.鸦胆子油乳联合多西紫杉醇+顺铂方案治疗非小细胞肺癌临床评价 [J].中国药业,2018,27(15):43~45.
[8] 范丽敬,陈学军,云游,等.低剂量CT灌注成像对盐酸安罗替尼治疗肺癌疗效的早期评估[J].实用放射学杂志,2019,35():977~980.
[9] 许立国.双源CT灌注成像对肺癌放化疗疗效评价及其与肿瘤血管生成的相关性研究[J].中国CT和MRI杂志,2018,16(10)80~82,153. |
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2021, Vol. 27 
