三七总皂苷联合氨基胍治疗对糖尿病肾病大鼠肾功能 血CRP TNF-α MDA和SOD水平的影响

doi:10.3969/j.issn.1006-6233.2021.09.002

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Abstract Objective: To explore the effects of panax notoginseng saponins combined with aminoguanidine treatment on renal function, blood C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA) and superoxide dismutase in diabetic nephropathy rats ( SOD) level. Methods: 75 clean-grade male SD rats were randomly divided into normal control group (15 rats) and experimental group (60 rats). The experimental group was intraperitoneally injected with streptozotocin to establish a rat model of diabetic nephropathy. The rats in the experimental group were randomly divided into model group (13 rats), PNS group (13 rats), AG group (13 rats), and combination group (13 rats). The rats were given corresponding drugs by gavage for 4 weeks. Observe the pathological changes of rat kidney tissues in each group, and compare the levels of glomerular volume, blood glucose, blood creatinine, 24h urine protein, plasma CRP, TNF-α, serum MDA and SOD in each group. Results: The glomerulus in the normal control group had a regular and complete appearance, with few mesangial cells and thin basement membrane; the shape of the renal tubules was clear, and the basement membrane was unchanged. The glomerulus of the experimental group was significantly enlarged, mesangial cells increase, basement membrane thickens, and renal tubules. There was no significant change; compared with the model group, the glomerular pathology of the PNS group, AG group, and combination group was significantly improved. The glomerular volume, blood glucose, blood creatinine, 24h urine protein, plasma CRP, and TNF-α level of the model group, PNS group, AG group, and combination group were higher than those of the normal control group, PNS group, AG group, and combination group. Blood glucose, blood creatinine, 24h urine protein, plasma CRP, and TNF-α level were lower than the model group. The combined group had higher glomerular volume, blood glucose, blood creatinine, 24h urine protein, plasma CRP, and TNF-α level than the PNS group. AG group: The differences were statistically significant (P<0.05). The MDA level of the model group, PNS group, AG group, and the combination group was higher than the normal control group, and the SOD level was lower than the normal control group; the MDA level of the PNS group, the AG group, and the combination group was lower than the model group, and the SOD level was higher than the model group; The SOD level of the group was higher than that of the AG group: the differences were statistically significant (P<0.05). Conclusion: PNS combined with AG treatment can significantly improve glomerular pathology and glomerular function in diabetic nephropathy, reduce plasma inflammatory factors CRP and TNF-α level, and reduce oxidative stress level.

Key words： Diabetic nephropathy Rats Renal function Oxidative stress Panax notoginseng saponins Aminoguanidine

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	Articles by authors
	ZHENG Jiehong
	ZHENG Yingmiao
	CHEN Fengwu

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ZHENG Jiehong,ZHENG Yingmiao,CHEN Fengwu. Effects of Panax Notoginseng Saponins Combined with Aminoguanidine Treatment on Renal Function Blood CRP TNF-α MDA and SOD Levels in Diabetic Nephropathy Rats[J]. HeBei Med, 2021, 27(9): 1414-1417.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.09.002 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I9/1414

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