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| Efficacy of Omeprazole Sodium Combined with Cimetidine in the Treatment of Elderly Peptic Ulcers and Its Effects on Levels of Serum Ghrelin and Leptin |
| HUANG Lina, XU Shuhui, ZHONG Shaojin, et al |
| The Affiliated Haikou Hospital of Xiangya Medical College, Central South University; Hainan Haikou 570208, China |
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Abstract Objective: To explore the efficacy of omeprazole sodium combined with cimetidine in the treatment of elderly peptic ulcers and its effects on levels of serum growth hormone releasing polypeptide (Ghrelin) and Leptin of patients. Methods: The elderly patients with peptic ulcer admitted to our hospital from April 2018 to January 2020 were numbered, and 146 cases were randomly selected by computer and divided into the combined group and the control group, 73 cases in each, according to the random number table method. Control group was treated with cimetidine sodium, and combined group was additionally administered omeprazole on the basis of control group. The efficacy after 3 weeks of treatment, symptom relief time, levels of gastrointestinal function [Leptin, gastrin, growth hormone releasing polypeptide (Ghrelin), motilin] and serum biochemical indicators [serum interleukin 6 (IL-6), high-sensitivity C-reaction protein (hs-CRP), superoxide dismutase (SOD), vascular endothelial growth factor (VEGF)] before and after treatment, adverse reactions and recurrence rates were compared between the two groups. Results: After treatment, the clinical efficacy of combined group was significantly better than that of control group (P<0.05). The hematochezia time, hematemesis time and melena disappearance time of combined group were shorter than those of control group while the Hp eradication rate was higher than that in control group (P<0.05), and there was no statistically significant difference in hospital stay between the two groups (P>0.05). After 3 weeks treatment, the levels of serum Leptin and gastrin in the two groups were significantly reduced (P<0.05) while the levels of Ghrelin and motilin were significantly increased (P<0.05), and the levels of serum IL-6 and hs-CRP were significantly decreased (P<0.05) while the levels of SOD and VEGF were significantly increased (P<0.05), and there were significant differences in the above indexes between the groups after treatment (P<0.05). During treatment, the incidence rate of adverse reactions was 5.48% in combined group and was 8.22% in control group, and there was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05). Within 6 months of follow-up after treatment, there were 2 cases of recurrence in combined group, the incidence rate was 2.74%, and there were 8 cases in control group, the incidence rate was 10.96%(P<0.05). Conclusion: Omeprazole sodium combined with cimetidine can significantly improve the clinical efficacy of elderly peptic ulcers, reduce serum inflammation and improve gastric function, with fewer adverse reactions and a lower recurrence rate.
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2021, Vol. 27 
