尿RBP 尿L-FABP 血FGF-21 TGF-β联合诊断早期糖尿病肾病的价值

doi:10.3969/j.issn.1006-6233.2021.08.027

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Abstract Objective: To analyze the value of urinary retinol binding protein (RBP), urinary liver-type fatty acid binding protein (L-FABP), blood fibroblast growth factor-21 (FGF-21) and transforming growth factor-β (TGF-β) in the diagnosis of early diabetic nephropathy (DN). Methods: The clinical data of 124 patients with type 2 diabetes mellitus treated in the hospital from January 2018 to January 2020 were retrospectively analyzed. The occurrence of DN in all patients was counted and divided into groups. Referred to the guidelines, the patients with DN were divided into different stages. Enzyme linked immunosorbent assay was used to analyze the levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β of patients. The levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β in the DN group and the non DN group were compared. The levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β of DN with different stages, the diagnostic efficacy of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β levels in patients with diabetes mellitus were analyzed. Results: Among 124 patients with type 2 diabetes mellitus, there were 35 patients with DN and 89 patients without DN; the levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β in DN group were all higher than those in non DN group, with a statistical significant difference (P<0.05); among the 35 cases of patients with DN, 12 cases were DN stage 1, 13 cases were DN stage 2 and 10 cases were DN stage 3; the levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β in DN stage 3 group respectively higher than those in DN stage 1 group and DN stage 2 group, with a statistical significant difference (P<0.05); comparing the levels of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β in DN stage 1 and 2 groups, there was no statistical significant difference (P>0.05); the area under the curve (AUC) of urinary RBP, urinary L-FABP, serum FGF-21, TGF-β alone and in combination of detection for the diagnosis of DN in patients with diabetes mellitus and the differentiation of DN stages were all >0.80, all with certain diagnostic and differential value. Conclusion: The combination of urinary RBP, urinary L-FABP, serum FGF-21 and TGF-β has high application value in the diagnosis of early DN, and can be used to differentiate the stages of DN.

Key words： Diabetic nephropathy Urinary retinol binding protein Urinary liver-type fatty acid binding protein Blood fibroblast growth factor-21 Transforming growth factor-β

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	MEI Xiaoxue
	MA Yumin
	ZHAO Yusong

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MEI Xiaoxue,MA Yumin,ZHAO Yusong. The Diagnosis Value of Urinary RBP Urinary L-FABP Serum FGF-21 and TGF-β in Combination for Early Diabetic Nephropathy[J]. HeBei Med, 2021, 27(8): 1358-1363.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.08.027 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I8/1358

[1] Furuichi K,Shimizu M,Yuzawa Y,et al.Clinicopathological analysis of biopsy-proven diabetic nephropathy based on the Japanese classification of diabetic nephropathy[J].Clin Exp Nephrol,2018,22(3):570~582.
[2] 钟开义,黎宝仁,张祖文,等.尿NGAL,L-FABP及RBP与老年2型糖尿病肾病的相关性研究[J].国际检验医学杂志,2020,41(10):1226~1229,1244.
[3] 黄丽君,占志平,张琳静,等.血清FGF-21,FGF-23在糖尿病肾病中的表达及其临床意义[J].标记免疫分析与临床,2020,27(4):598~602.
[4] 张洪江,凃影叶,杜飞,等.TGF-β参与糖尿病肾病的发生发展的机制研究现状[J].生命科学,2020,32(2):179~187.
[5] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447~498.
[6] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292~344.
[7] Chen C,Wang C,Hu C,et al.Normoalbuminuric diabetic kidney disease[J].Front Med,2017,11(3):310~318.
[8] 李昌艳,刘娟,顾芳,等.2型糖尿病患者进展为早期糖尿病肾脏病的影响因素分析[J].中国全科医学,2020,23(26):3291~3296.
[9] Wu J,Shao X H,Lu K,et al.Urinary RBP and NGAL levels are associated with nephropathy in patients with type 2 diabetes[J].Cell Physiol Biochem,2017,42(2):594~602.
[10] 崔彩侠.肝型脂肪酸结合蛋白在糖尿病肾病中的作用及研究进展[J].国际泌尿系统杂志,2018,38(3):524~527.
[11] Ito H,Yamashita H,Nakashima M,et al.Current Metabolic status affects urinary liver-type fatty-acid binding protein in normoalbuminuric patients with type 2 diabetes[J].Clin Med Res,2017,9(4):366~373.
[12] Esteghamati A,Khandan A,Momeni A,et al.Circulating levels of fibroblast growth factor-21 in early-stage diabetic kidney disease[J].Ir Med Sci,2017,186(3):785~794.
[13] Suassuna P G A,de Paula R B,Sanders-Pinheiro H,et al.Fibroblast growth factor-21 in chronic kidney disease[J].Nephrol,2019,32(3):365~377.
[14] 姚向飞,蔡东,权皎洁.2型糖尿病肾病患者外周血IGF-1、TGF-β和VEGF水平及临床意义[J].解放军医药杂志,2017,29(6):78~81.
[15] 莫翠瑶,章毅,杨静,等.不同糖耐量水平病人AngⅡ、TGF-β与肾功能的相关性研究[J].中西医结合心脑血管病杂志,2019,17(14):2178~2180.