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| Efficacy of Continuous Renal Replacement Therapy on Acute Renal Failure and Its Effects on Levels of T Lymphocytes Inflammatory Factors and Serum Electrolytes |
| HAN Ruiping, et al |
| Wuhan First Hospital, Hubei Wuhan 430000, China |
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Abstract Objective: To observe the efficacy of continuous renal replacement therapy (CRRT) on acute renal failure (ARF) and its effects on levels of T lymphocytes, inflammatory factors and serum electrolytes. Methods: A total of 161 patients with ARF treated in the hospital were randomly divided into observation group (n=81) and control group (n=80) according to simple random sampling. On the basis of conventional treatment, patients in control group were treated with intermittent hemodialysis (IHD), and patients in observation group were administered CRRT. The clinical efficacy of the two groups of patients was compared, and the changes in immune function indicators (CD3+, CD4+, CD8+, CD4+/CD8+), inflammatory factors [interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α)], serum electrolytes [potassium (K+), sodium (Na+), chlorine (Cl-)] and renal function indicators [blood urea nitrogen (BUN), serum creatinine (Scr), endogenous creatinine clearance rate (Ccr), β2 microglobulin (β2-MG)] were observed in the two groups before treatment and after 3 months of treatment. Results: The total clinical effective rate of observation group was significantly higher than that of control group (96.3% vs 87.5%) (P<0.05). After 3 months of treatment, the levels of CD3+, CD4+, CD4+/CD8+ and Ccr in the two groups of patients were higher than those before treatment, and the differences before and after treatment between the two groups were statistically significant (P<0.05). The levels of CD8+, IL-1, IL-6 , IL-8, TNF-α, K+, Na+, Cl-, BUN, Scr and β2-MG were lower in the two groups of patients than those before treatment, and the differences before and after treatment were statistically significant between the two groups (P<0.05). Conclusion: CRRT has a significant effect in the treatment of patients with ARF. It can reduce the levels of inflammatory factors, regulate the levels of electrolytes, enhance the body’s immunity, and improve the renal function.
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2021, Vol. 27 
