血清SFRP1水平与慢性阻塞性肺疾病急性加重期患者炎症反应及肺功能的关系

doi:10.3969/j.issn.1006-6233.2021.08.015

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Abstract Objective: To investigate the relationship between serum SFRP1 level and inflammatory response and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods: 150 patients of COPD in our hospital from March 2019 to October 2020 were selected, including 86 patients in acute exacerbation stage and 64 patients in stable stage, and 60 healthy people in the same period as the control group. The levels of serum SFRP1, inflammatory factors [interleukin-17 (IL-17), IL-33, high sensitivity reactive protein (hs-CRP), tumor necrosis factor - α (TNF - α)] and lung function [the first group] were compared. The correlation was analyzed between serum SFRP1 level and inflammatory factors, lung function in patients with acute exacerbation of COPD. Receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic value of serum SFRP1 in acute exacerbation of COPD. Results: Levels of serum SFRP1 and inflammatory factors of the acute exacerbation group were significantly higher than those in the stable group and the control group, and the above indexes in the stable group were also higher than those in the control group(P<0.05).The lung function of acute exacerbation group were significantly lower than those of stable group and control group, and lung function of stable group was significantly lower than that of control group(P<0.05). Serum SFRP1 level of acute exacerbation patients was positive correlated with serum IL-17, IL-33, hs-CRP and TNF-α (r=0.537, 0.508, 0.403, 0.442,P<0.05),and was negative correlated with FEV1,FEV1/FVC(r=-0.524, -0.576, P<0.05). ROC curve showed that the cut-off value of serum SFRP1 level for predicting acute exacerbation of COPD was 75.43 pg/ml, the sensitivity and specificity for predicting acute exacerbation of COPD were 89.78% and 92.03%, which were consistent with the diagnostic criteria of acute exacerbation of COPD (kappa=0.835). Conclusion: The serum SFRP1 level in patients of acute exacerbation of COPD is positively correlated with serum inflammatory factors, negatively correlated with FEV1 and FEV1 / FVC. The serum SFRP1 level has a good diagnostic value for acute exacerbation of COPD.

Key words： Chronic obstructive pulmonary disease Inflammatory response Lung function Secretory curl associated protein 1 Diagnostic value

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	HAN Xiang
	WU Weiqin
	ZHAO Hongmei

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HAN Xiang,WU Weiqin,ZHAO Hongmei. Relationship Between Serum SFRP1 Level and Inflammatory Response and Pulmonary Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J]. HeBei Med, 2021, 27(8): 1304-1308.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.08.015 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I8/1304

[1] GBD 2015 Chronic Respiratory Disease Collaborators.Global,regional,and national deaths,prevalence,disability-adjusted life years,and years lived with disability for chronic obstructive pulmonary disease and asthma,1990-2015:a systematic analysis for the Global Burden of Disease Study 2015[J].Lancet Respir Med,2017,5(9):691~706.
[2] Mirza S,Clay RD,Koslow MA,et al.COPD guidelines:a review of the 2018 GOLD report[J].Mayo Clin Proc,2018,93(10):1488~1502.
[3] Cisneros E,di Marco F,Rueda-Carrasco J,et al.Sfrp1 deficiency makes retinal photoreceptors prone to degeneration[J].Sci Rep,2020,10(1):5115.
[4] 中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.慢性阻塞性肺疾病基层诊疗指南(2018年)[J].中华全科医师杂志,2018,17(11):856~870.
[5] Duffy SP,Criner GJ.Chronic obstructive pulmonary disease:evaluation and management[J].Med Clin North Am,2019 ,103(3):453~461.
[6] Dufourcq P,Leroux L,Ezan J,et al.Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway:role in neovessel formation[J].Am Pathol,2008,172(1):37~49.
[7] Faisy C,Grassin-Delyle S,Blouquit-Laye S,et al.Wnt/β-catenin signaling modulates human airway sensitization induced by β2-adrenoceptor stimulation[J].PLoS One,2014,9(10):e111350.
[8] Hay E,Nouraud A,Marie PJ.N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt,ERK and PI3K/Akt signalling[J].PLoS One,2009,4(12):e8284.
[9] Foronjy R,Imai K,Shiomi T,et al.The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema[J].Am Pathol,2010 ,177(2):598~607.
[10] Barnes PJ.Inflammatory mechanisms in patients with chronic obstructive pulmonary disease[J].Allergy Clin Immunol,2016,138(1):16~27.
[11] Frieder J,Kivelevitch D,Haugh I,et al.Anti-IL-23 and anti-IL-17 biologic agents for the treatment of immune-mediated inflammatory conditions[J].Clin Pharmacol Ther,2018,103(1):88~101.
[12] Cayrol C,Girard JP.Interleukin-33 (IL-33):a nuclear cytokine from the IL-1 family[J].Immunol Rev,2018 ,281(1):154~168.
[13] Moutachakkir M,Lamrani Hanchi A,Baraou A,et al.Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein[J].Ann Biol Clin (Paris),2017,75(2):225~229.
[14] Ma K,Zhang H,Baloch Z.Pathogenetic and therapeutic applications of tumor necrosis factor-α (TNF-α) in major depressive disorder:a systematic review[J].Int Mol Sci,2016,17(5):733.
[15] Quan H,Zhou F,Nie D,et al.Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition[J].Oncogene,2014 ,33(22):2826~2835.