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| Observation on Application of Carbon Nanoparticles Suspension Injection labeling in laparoscopic Radical Gastrectomy |
| XIAO Hua, CAO Hongyong, SHI Xuesong |
| Nanjing First Hospital Affiliated to Nanjing Medical University, Jiangsu Nanjing 210006, China |
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Abstract Objective: To analyze the application value of Carbon Nanoparticles Suspension Injection labeling in laparoscopic radical gastrectomy. Methods: The clinical data of 86 patients who underwent D2 radical resection of laparoscopic distal gastric cancer in our hospital were retrospectively analyzed. Among them, 46 patients were given intraoperative Carbon Nanoparticles Suspension Injection labeling (observation group) and 40 patients were not treated with intraoperative Carbon Nanoparticles Suspension Injection labeling (control group). The perioperative status, lymph node dissection and metastasis, postoperative complications and survival at 1 year after operation were recorded in the two groups. The differences of traumatic stress status [cortisol (Cor), β-endorphin (β-EP)] were compared between the two groups before operation and at 1 d after operation. Results: There were no significant differences in operative time, intraoperative blood loss, postoperative exhaust time, postoperative hospital stay and incidence rates of postoperative complications between the two groups (P>0.05). The quantities of lymph nodes and micro-lymph nodes dissection, quantity of lymph node metastasis and lymph node metastasis rate in observation group were higher than those in control group (P<0.05). At 1 year after operation, there were no death cases in both groups, but there were recurrence cases. Kaplan-Meier survival curve and Log Rank test showed that the tumor-free survival rate of observation group was significantly higher than that of control group (93.5% vs 77.50%) (P<0.05). At 1 d after operation, the traumatic stress (Cor, β-EP) was higher than that before operation (P<0.05), but there were no significant differences in serum Cor and β-EP levels between the two groups (P>0.05). Conclusion: Intraoperative Carbon Nanoparticles Suspension Injection labeling can enhance the lymph node dissection effects of laparoscopic radical gastrectomy, increase the rate of lymph node dissection, and improve the postoperative tumor-free survival rate of patients, with a high application value.
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2021, Vol. 27 
