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Effects of Laparoscopic Radical Gastrectomy on Energy Metabolism Peripheral Blood TCell Subsets Intestinal Barrier Function Body's Inflammatory Stress Level and Immune Function in Patients with Gastric Cancer |
DAI Mengshuang, ZHANG Feng, JIA Tingting, et al |
Panzhihua Central Hospital, Sichuan Panzhihua 617000, China |
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Abstract Objective: To explore the effects of laparoscopic radical gastrectomy on energy metabolism, peripheral blood T cell subsets, intestinal barrier function, body’ s inflammatory stress level and immune function in patients with gastric cancer. Methods: A total of 142 patients with gastric cancer admitted to our hospital from June 2017 to June 2020 were selected as the research subjects. According to the surgical methods, 142 patients were divided into laparoscopic surgery group (observation group, n=75) and open surgery group (control group, n=67). The energy metabolism [albumin (ALB), prealbumin (PA), retinol binding protein (RBP), transferrin (TRF)], intestinal barrier function [diamine oxidase (DAO), D-lactic acid], inflammatory stress level [C reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], peripheral blood T cell subsets (CD4+, CD8+, CD4+/CD8+) and immunoglobulins (IgA, IgG, IgM) were compared between the two before and after surgery. Results: At 3 days after surgery, the levels of serum ALB, PA, RBP, TRF, TNF-α, IgA, IgG and IgM and peripheral blood CD4+ and CD4+/CD8+in the two groups were decreased compared with those before surgery(P<0.05). At 3d after surgery, the levels of plasma DAO and D-lactic acid and serum CRP in the two groups were increased compared with those before surgery (P<0.05). At 1 day after surgery, the level of serum IL-6 in the two groups was higher than that before surgery (P<0.05). The changes of above indexes before and after surgery in observation group were lower than those in control group (P<0.05). Conclusion: Compared with open surgery, laparoscopic radical gastrectomy has less effect on energy metabolism, intestinal barrier function, inflammatory stress level and immune function, and it is beneficial to postoperative recovery.
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