还原型谷胱甘肽联合多烯磷脂酰胆碱对急性药物性肝损害患者CRP IL-6 PCT及肝功能的影响

doi:10.3969/j.issn.1006-6233.2021.07.004

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Abstract Objective: To explore the effect of reduced glutathione combined with polyene phosphatidylcholine on CRP, IL-6, PCT and liver function in patients with acute drug-induced liver injury. Methods: The clinical data of 68 patients with acute drug-induced liver damage were selected for retrospective analysis from January 2018 to January 2020. According to different treatment drugs, they were divided into control group (treated with polyene phosphatidylcholine) and observation group (treated with reduced glutathione combined with polyene phosphatidylcholine), 34 cases in each group. The CRP, IL-6, PCT, TBIL, ALT, AST, GGT, TBA, MELD score, Child-Pugh score and adverse reactions (allergic rash, stomach discomfort, diarrhea) were observed and evaluated in the two groups. Results: After 4 weeks and 8 weeks of treatment, the CRP, IL-6, PCT, TBiL, ALT, AST, GGT, TBA, MELD scores and Child-Pugh scores of the observation group were lower than those of the control group (all P<0.05). The incidence of adverse reactions in the observation group was 11.76%, which was the same as the control group (χ²=0.159, P>0.05). Conclusion: Reduced glutathione combined with polyene phosphatidylcholine treatment can not only improve liver function, but also reduce inflammation, and has high safety and a good prognosis.

Key words： Reduced glutathione Polyene phosphatidylcholine Drug-induced liver injury

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	LI Congying
	YANG Zhanjiang
	DU Guangqing

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LI Congying,YANG Zhanjiang,DU Guangqing. The Effect of Reduced Glutathione Combined with Polyene Phosphatidylcholine on CRP IL-6 PCT and Liver Function in Patients with Acute Drug-Induced Liver Injury[J]. HeBei Med, 2021, 27(7): 1076-1080.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.07.004 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I7/1076

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