血浆循环微小RNA-126 微小RNA-155与老年冠心病患者冠状动脉支架内再狭窄的相关性分析

doi:10.3969/j.issn.1006-6233.2021.06.020

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Abstract Objective: To detect the expressions of plasma circulation microRNA-126 (miR-126) and microRNA-155 (miR-155) in elderly patients with coronary heart disease, and to explore the correlation between their expression levels and the occurrence of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Methods: From August 2017 to September 2019, 135 elderly patients with coronary heart disease confirmed by coronary angiography and percutaneous coronary intervention (PCI) in our hospital were selected as the study objects, coronary angiography was performed 1 year after operation, and the patients were divided into restenosis group (n = 39) and non restenosis group (96). The expression levels of miR-126 and miR-155 were detected by real-time fluorescence quantitative PCR (qRT-PCR); the diagnostic value of plasma circulation miR-126 and miR-155 expressions in elderly patients with coronary heart disease who had ISR after PCI was evaluated by receiver operating characteristic curve (ROC); and Logistic regression analysis was used to analyze the influencing factors of ISR in elderly patients with coronary heart disease after PCI. Results: The expression levels of plasma miR-126 and miR-155 in the restenosis group were significantly lower than those in the non-restenosis group (P<0.05). ROC results showed that AUC of plasma miR-126 and miR-155 was 0.843 and 0.708, respectively, and the cutoff value was 3.158 and 1.424, respectively, at this time, the corresponding sensitivity was 74.0% and 59.4%, and the specificity was 82.1% and 76.9%, respectively; the AUC of ISR after PCI in elderly patients with coronary heart disease detected by plasma circulation miR-126 combined with miR-155 was 0.864, and the corresponding sensitivity and specificity were 79.2% and 84.6%, respectively. Logistic analysis showed that low expressions of miR-126 and miR-155 in plasma circulation were independent risk factors for ISR in elderly patients with coronary heart disease after PCI. Conclusion: The expressions of plasma circulation miR-126 and miR-155 significantly decreased among elderly patients with coronary heart disease who had ISR after PCI and they participate in the occurrence and development of ISR in elderly patients with coronary heart disease after PCI, therefore, it is suggested that miR-126 and miR-155 in plasma circulation may be potential biological indicators for diagnosis and disease assessment of elderly patients with coronary heart disease who had ISR after PCI.

Key words： Coronary heart disease in the elderly Coronary artery in-stent restenosis MicroRNA-126 MicroRNA-155 Correlation

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	DU Yue
	LI Sha
	XIAO Ming
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DU Yue,LI Sha,XIAO Ming, et al. An Analysis of the Correlation Between Plasma Circulation MiR-126 MiR-155 and In-Stent Restenosis in Elderly Patients with Coronary Heart Disease[J]. HeBei Med, 2021, 27(6): 975-979.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2021.06.020 OR http://www.hbyxzzs.cn/EN/Y2021/V27/I6/975

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